Prostaglandins and nitric oxide mediate insulin-induced vasodilation in the human forearm

Veen, Saskia van; Chang, P. C.

doi:10.1016/s0008-6363(97)00031-x

Cited by 24 publications

(20 citation statements)

References 38 publications

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“…Moreover, as it was also previously shown (12,20,32,33,35,(37)(38)(39), insulin infusion caused vasodilation, probably by its local effects on nitric oxide release (32,35,36), resulting in muscle blood flow increase, which is mainly due to an increase in nutritive capillaries blood flow (8). The increase in blood flow was similar in the exercise and control sessions.…”

Section: Discussionsupporting

confidence: 73%

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Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Bisquolo¹,

Cardoso²,

Ortega³

et al. 2005

Journal of Applied Physiology

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. Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia. J Appl Physiol 98: 866 -871, 2005. First published November 12, 2004 doi:10.1152/japplphysiol.00251.2004.-Insulin infusion causes muscle vasodilation, despite the increase in sympathetic nerve activity. In contrast, a single bout of exercise decreases sympathetic activity and increases muscle blood flow during the postexercise period. We tested the hypothesis that muscle sympathetic activity would be lower and muscle vasodilation would be higher during hyperinsulinemia performed after a single bout of dynamic exercise. Twenty-one healthy young men randomly underwent two hyperinsulinemic euglycemic clamps performed after 45 min of seated rest (control) or bicycle exercise (50% of peak oxygen uptake). Muscle sympathetic nerve activity (MSNA, microneurography), forearm blood flow (FBF, plethysmography), blood pressure (BP, oscillometric method), and heart rate (HR, ECG) were measured at baseline (90 min after exercise or seated rest) and during hyperinsulinemic euglycemic clamps. Baseline glucose and insulin concentrations were similar in the exercise and control sessions. Insulin sensitivity was unchanged by previous exercise. During the clamp, insulin levels increased similarly in both sessions. As expected, insulin infusion increased MSNA, FBF, BP, and HR in both sessions (23 Ϯ 1 vs. 36 Ϯ 2 bursts/min, 1.8 Ϯ 0.1 vs. 2.2 Ϯ 0.2 ml ⅐ min Ϫ1 ⅐ 100 ml Ϫ1 , 89 Ϯ 2 vs. 92 Ϯ 2 mmHg, and 58 Ϯ 1 vs. 62 Ϯ 1 beats/min, respectively, P Ͻ 0.05). BP and HR were similar between sessions. However, MSNA was significantly lower (27 Ϯ 2 vs. 31 Ϯ 2 bursts/min), and FBF was significantly higher (2.2 Ϯ 0.2 vs. 1.8 Ϯ 0.1 ml ⅐ min Ϫ1 ⅐ 100 ml Ϫ1 , P Ͻ 0.05) in the exercise session compared with the control session. In conclusion, in healthy men, a prolonged bout of dynamic exercise decreases MSNA and increases FBF. These effects persist during acute hyperinsulinemia performed after exercise.

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Section: Discussionsupporting

confidence: 73%

“…However, it is interesting that acute insulin infusion does not always result in blood pressure (BP) increase (5,38,39). This apparent paradox can be explained by the insulin-induced muscle vasodilation (12,20,32,33,35,(37)(38)(39) that counteracts the pressor effect of sympathetic activation.…”

mentioning

confidence: 99%

Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Bisquolo¹,

Cardoso²,

Ortega³

et al. 2005

Journal of Applied Physiology

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“…22 This action of insulin is mediated by endothelially-derived nitric oxide 24 which may subsequently stimulate prostaglandin release. 25,26 There is also some evidence that insulin modulates an endothelial nitric oxide component of the a 2 -and b-adrenergic vascular responses in the human forearm. 27 As expected, an increase in noradrenaline concentrations was seen in our study.…”

Section: Discussionmentioning

confidence: 99%

The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat

et al. 2001

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OBJECTIVE:To investigate the factors regulating the increase in adipose tissue blood flow following meals. DESIGN: Eight subjects were fed three isoenergetic meals; two high-fat meals rich in either saturated or polyunsaturated fatty acids and one low-fat, high-carbohydrate meal. MEASUREMENTS: Blood samples were taken and adipose tissue blood flow was measured before and for 6 h after the meal. Plasma glucose, insulin, non-esterified fatty acid, total and chylomicron-triacylglycerol and catecholamine concentrations were measured. RESULTS: Adipose tissue blood flow rose to a peak after all three meals (P < 0.05 for each). The three meals stimulated adipose tissue blood flow at similar times. There was a marked and statistically significant similarity in the time course of changes in blood flow and insulin concentrations. In contrast, noradrenaline concentrations peaked later than adipose tissue blood flow (P ¼ 0.014). CONCLUSION: Adipose tissue blood flow may be 'carbohydrate-stimulated' rather than 'fat-stimulated', with insulin having a vasodilatory role in adipose tissue as in skeletal muscle.

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“…The acute vascular effect of insulin in healthy men is vasodilation by stimulation of nitric oxide production and secondarily by stimulation of vasodilating prostaglandins. 3,4 Early in the course of insulin-dependent diabetes mellitus (IDDM), before the occurrence of overt retinopathy, a decrease in retinal blood flow is present that correlates with plasma glucose levels. 5 In contrast, in IDDM with poor metabolic control, elevated cardiac output and forearm blood flow Correspondence: Dr PC Chang, Department of Nephrology, C3-P, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands Received 9 July 1998; revised and accepted 19 October 1998 vascular resistance were related to the plasma glucose concentrations both glucose infusions were equipotent.…”

Section: Introductionmentioning

confidence: 99%

Acute hyperglycaemia in the forearm induces vasodilation that is not modified by hyperinsulinaemia

Veen¹,

Frölich

1999

J Hum Hypertens

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Objective: To evaluate whether acute elevations of local plasma glucose concentrations could influence forearm blood flow (FBF) and how this interacts with local hyperinsulinaemia in healthy volunteers. Methods: Using the perfused forearm technique, in random order, glucose 20% or saline 0.9% as a control was infused in three dose steps (0.3, 1.0, and 3.0 ml/min) for 5 min each in eight healthy men. The infusion experiments were repeated, in random order, during local hyperinsulinaemia by intra-arterial infusion of insulin 0.05 mU/kg/min. The ratio of FBF of the infused over the FBF in the control arm (FR) was measured at 15-sec intervals during the infusions. Results: Glucose infusion increased the FR dosedependently by 172% ± 39% (M ± SE) at the highest dose (P Ͻ 0.01). During hyperinsulinaemia the glucoseinduced increase in FR was significantly (P Ͻ 0.01) less, 96% ± 26%, however, when changes in FR or forearm

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Prostaglandins and nitric oxide mediate insulin-induced vasodilation in the human forearm

Abstract: Insulin has vasodilating properties in skeletal muscle vasculature that is mediated by increases in nitric oxide, that subsequently stimulates prostaglandin release. The latter appears to be a novel vascular action of insulin.

Cited by 24 publications

References 38 publications

Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat

Acute hyperglycaemia in the forearm induces vasodilation that is not modified by hyperinsulinaemia

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