2019
DOI: 10.1038/s42255-019-0097-9
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: A moderate reduction of body temperature can induce a remarkable lifespan extension. Here we examine the link between cold temperature, germ line fitness and organismal longevity. We show that low temperature reduces age-associated exhaustion of germ stem cells (GSCs) in Caenorhabditis elegans , a process modulated by thermosensory neurons. Notably, robust self-renewal of adult GSCs delays reproductive aging and is required for extended lifespan at cold temperatures. These cells release … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
37
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 30 publications
(39 citation statements)
references
References 90 publications
2
37
0
Order By: Relevance
“…Of the eight genes that we tested, the knockdown of five genes, alh-3, atic-1, cbs-1, cth-2, and sams-1, abrogate FMO-2 OE resistance against paraquat (Figure 2B-F), as assessed using log-rank test with a cutoff threshold of p < 0.0001 28 compared to the empty vector (EV) controls. Our data for the knockdowns of alh-3, atic-1, and cbs-1 are consistent with previous reports that their expression levels are upregulated in long-lived worms 11,29 . alh-3 is upregulated in eat-2 mutants, atic-1 is upregulated in both eat-2 and daf-2 mutants, and cbs-1 is upregulated under cold-induced longevity and is required for the lifespan extension of eat-2 and glp-1 mutants 11,[29][30][31] .…”
Section: One Carbon Metabolism Interacts With Fmo-2 To Regulate Stressupporting
confidence: 92%
See 1 more Smart Citation
“…Of the eight genes that we tested, the knockdown of five genes, alh-3, atic-1, cbs-1, cth-2, and sams-1, abrogate FMO-2 OE resistance against paraquat (Figure 2B-F), as assessed using log-rank test with a cutoff threshold of p < 0.0001 28 compared to the empty vector (EV) controls. Our data for the knockdowns of alh-3, atic-1, and cbs-1 are consistent with previous reports that their expression levels are upregulated in long-lived worms 11,29 . alh-3 is upregulated in eat-2 mutants, atic-1 is upregulated in both eat-2 and daf-2 mutants, and cbs-1 is upregulated under cold-induced longevity and is required for the lifespan extension of eat-2 and glp-1 mutants 11,[29][30][31] .…”
Section: One Carbon Metabolism Interacts With Fmo-2 To Regulate Stressupporting
confidence: 92%
“…Our data for the knockdowns of alh-3, atic-1, and cbs-1 are consistent with previous reports that their expression levels are upregulated in long-lived worms 11,29 . alh-3 is upregulated in eat-2 mutants, atic-1 is upregulated in both eat-2 and daf-2 mutants, and cbs-1 is upregulated under cold-induced longevity and is required for the lifespan extension of eat-2 and glp-1 mutants 11,[29][30][31] . cth-2 is a homolog of the transsulfuration pathway enzyme cystathionine g-lyase that is detrimental to the wild type lifespan when its expression is suppressed using RNAi 30 .…”
Section: One Carbon Metabolism Interacts With Fmo-2 To Regulate Stressupporting
confidence: 92%
“…Given the cumulative evidence that demonstrates a role of the germ line in the regulation of somatic function ( 8 10 , 47 , 48 ), here, we asked whether changes in the proteostasis status of germline cells can affect distal tissues. To identify long-range, cell nonautonomous mechanisms triggered by germline cells, we performed loss-of-function experiments of CEY proteins.…”
Section: Discussionmentioning
confidence: 99%
“…Changes in temperature can have remarkable effects on both the physiology and development of organisms. For example, temperature decrease is known to extend lifespan and a recent study in C. elegans showed that this acts through reduction of age-mediated exhaustion of germline stem cells (Lee et al . 2019).…”
Section: Discussionmentioning
confidence: 99%