Prostaglandin e<sub>1</sub> (pge<sub>1</sub>) suppression of adjuvant arthritis histopathology

Zurier, Robert B.; Ballas, Maurice

doi:10.1002/art.1780160218

Cited by 51 publications

(10 citation statements)

References 22 publications

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“…PGE is considered to be a mediator of acute-phase inflammation since it increases vascular permeability [25]. In contrast, PGEs also exert anti-inflammatory effects in chronic inflammations [25] and also suppress adjuvant arthritis in rat [26]. Furthermore, PGE2 effectively inhibits the synthesis of inflammatory cytokine of IL-1 in macrophages [27].…”

Section: Discussionmentioning

confidence: 99%

Cyclooxygenase inhibitors augment the production of pro‐matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes

et al. 1995

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Matrix metalloproteinase 9 (MMP-91gelatinase B) has recently been proposed to participate in the destruction of articular cartilage. Here, we report that interleukin 1 ([L-l) enhances the production of the precursor of MMP-9 in rabbit articular chondrocytes in primary culture, and this IL-l-mediated production of proMMP-9 is greatly augmented by cyclooxygenase inhibitors such as diclofenac and indomethacin, whereas the constitutive production of proMMP-2 (progelatinase A) is not modulated by IL-1 and/or cyclooxygenase inhibitors. Exogenous prostaglandin (PG) E1 and PGE2 suppress the proMMP-9 production in a dose-dependent manner. Similar results are also obtained with cultured rabbit synoviocytes. These results provide the first evidence that PGE down-regulates the production of proMMP-9 in chondrocytes and synoviocytes. Thus, cyclooxygenase inhibitors probably exert undesirable catabolic actions on the maintenance of articular cartilage under inflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

Cyclooxygenase inhibitors augment the production of pro‐matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes

et al. 1995

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“…It is therefore unlikely that the anti-inflammatory action of 401 depends upon its irritant properties. Nonetheless, it remains possible that the anti-inflammatory property of 401 may be in some way related to mast cell degranulation or other tissue damage since large doses of prostaglandin El (1 mg/day) reduce the severity of adjuvant arthritis (Zurier & Ballas, 1973) and alkylpseudothioureas reduce inflammatory reactions to a wide range of stimuli (Ercoli, Arbona & Tabernero, 1971).…”

Section: Effect Of 401 On Turpentine and Carrageenin Oedemamentioning

confidence: 99%

ANTI‐INFLAMMATORY PROPERTY OF 401 (MCD‐PEPTIDE), A PEPTIDE FROM THE VENOM OF THE BEE Apis mellifera (L.)

Hanson

Morley

Soria-Herrera

1974

British J Pharmacology

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Peptide 401, a potent mast cell degranulating factor from bee venom, substantially inhibited the oedema provoked by subplantar injection of carrageenin or intra‐articular injection of turpentine in the rat. The ED50 of 401 was c. 0.1 mg/kg. The anti‐inflammatory effect was assessed by measurement of the increased 125I‐albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppressed the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5‐hydroxytryptamine (5‐HT), and prostaglandins). Other comparable mast cell degranulating agents (48/80 and melittin) showed little evidence of anti‐inflammatory activity when tested at comparable dosage on turpentine arthritis and carrageenin oedema. The anti‐inflammatory effects were not abolished by pretreatment with mepyramine and methysergide, which abolished the increased vascular permeability produced by local injection of 401. The anti‐inflammatory action of 401 was not affected by regional denervation or pretreatment with phenoxybenzamine, and was reduced but not abolished by adrenalectomy. Measurement of skin temperature, fractional extraction of 86Rb and blood flow in perfused mesentery gave no evidence that the anti‐inflammatory action of 401 was due to reduced tissue perfusion. It is concluded that 401 may exert its anti‐inflammatory action directly by making the vascular endothelium anergic to phlogistic stimuli.

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“…Thus PGE compounds, which increase levels of cyclic 3'5'-adenosine monophosphate (CAMP) in human leucocytes (1 0, 11) reduce selective extrusion of lysosomal enzymes from human leukocytes in vitro (12, 13), prevent release of histamine and SRS-A from basophiles and lung fragments (14, 15), and prevent lymphocyte-mediated cytotoxicity (1 6). PGE, and PGE, also suppress adjuvantinduced arthritis and cartilage destruction in rats (17)(18)(19)(20), and CAMP treatment suppresses acute and chronic inflammation in several experimental models (21). These data suggest that prostaglandin E compounds, acting via CAMP, may inhibit as well as mediate, acute and chronic inflammation.…”

mentioning

confidence: 72%

“…PGE, and PGE, increase steroidogenesis (26,27) suggesting that their apparent antiinflammatory effect in rats with adjuvant arthritis (17)(18)(19)(20) might be due to stimulation of the pituitary-adrenal axis. Although PGE, does not consistently produce elevations in plasma corticosterone in rats with acljuvant disease as it does in normal rats (2X), an ACTH-like action cannot be excluded as the basis for the effects of PGE compounds on arthritis.…”

mentioning

confidence: 99%

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins

Zurier

Hoffstein

Weissmann

1973

Arthritis & Rheumatism

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Prostaglandin El (PGE,) suppressed acute carrageenan-induced inflammation and chronic joint inflammation characteristic of adjuvant disease in the rat. Placement of PGE, into subcutaneous air blebs at the time of carrageenan injection retarded movement of polymorphonuclear leukocytes into the focus of inflammation and produced a concentrationdependent reduction in exudate p-glucuronidase and lactate dehydrogenase activities, an effect also observed in adrenalectomized rats. PGE, also significantly reduced enzyme activities released into inflammatory exudates. Ultrastructural studies indicated that carrageenan was ingested by invading polymorphs and enclosed within phagocytic vacuoles, the membranes of which subsequently ruptured. More lysosomes remained intact after carrageenan uptake in bleb leukocytes from PGE,-treated than from control rats and there was no loss of phagosomal membrane integrity in cells from treated rats. Treatment of adrenalectomized rats with PGE, (300 pg twice daily) prevented adjuvant-induced systemic arthritis, reduced the acute inflammatory reaction at the site of adjuvant injection, and reduced the number of circulating small lymphocytes. Together, these two sets of experiments suggest that pharmacologic doses of prostaglandins are anti-inflammatory in acute and chronic models, and that the effect is not mediated entirely by stimulation of the pituitary and/or adrenal glands.Prostaglandins, a class of 20 carbon fatty acids containing a cyclopentane ring (I ), are

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Prostaglandin e₁ (pge₁) suppression of adjuvant arthritis histopathology

Cited by 51 publications

References 22 publications

Cyclooxygenase inhibitors augment the production of pro‐matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes

Cyclooxygenase inhibitors augment the production of pro‐matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes

ANTI‐INFLAMMATORY PROPERTY OF 401 (MCD‐PEPTIDE), A PEPTIDE FROM THE VENOM OF THE BEE Apis mellifera (L.)

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins

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Prostaglandin e1 (pge1) suppression of adjuvant arthritis histopathology

Cited by 51 publications

References 22 publications

Cyclooxygenase inhibitors augment the production of pro‐matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes

Cyclooxygenase inhibitors augment the production of pro‐matrix metalloproteinase 9 (progelatinase B) in rabbit articular chondrocytes

ANTI‐INFLAMMATORY PROPERTY OF 401 (MCD‐PEPTIDE), A PEPTIDE FROM THE VENOM OF THE BEE Apis mellifera (L.)

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins

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Prostaglandin e₁ (pge₁) suppression of adjuvant arthritis histopathology