Prospects for liver fluke vaccines

Zhang, Jing; Sun, Ying; Zheng, Jiahong

doi:10.1016/j.exppara.2021.108170

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…One of the main pathogens of fasciolosis in cattle and sheep is F. hepatica , which causes enormous economic losses to the livestock industry. No suitable commercial vaccines are available because of the immune evasion strategies of these parasites [ 126 ]. Cathepsin L1 and L2 (CL1 and CL2) are cysteine proteases that induce parasite penetration into host tissues.…”

Section: Resultsmentioning

confidence: 99%

Aspects of Phage-Based Vaccines for Protein and Epitope Immunization

Palma¹

2023

Vaccines

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Because vaccine development is a difficult process, this study reviews aspects of phages as vaccine delivery vehicles through a literature search. The results demonstrated that because phages have adjuvant properties and are safe for humans and animals, they are an excellent vaccine tool for protein and epitope immunization. The phage genome can easily be manipulated to display antigens or create DNA vaccines. Additionally, they are easy to produce on a large scale, which lowers their manufacturing costs. They are stable under various conditions, which can facilitate their transport and storage. However, no medicine regulatory agency has yet authorized phage-based vaccines despite the considerable preclinical data confirming their benefits. The skeptical perspective of phages should be overcome because humans encounter bacteriophages in their environment all the time without suffering adverse effects. The lack of clinical trials, endotoxin contamination, phage composition, and long-term negative effects are some obstacles preventing the development of phage vaccines. However, their prospects should be promising because phages are safe in clinical trials; they have been authorized as a food additive to avoid food contamination and approved for emergency use in phage therapy against difficult-to-treat antibiotic-resistant bacteria. Therefore, this encourages the use of phages in vaccines.

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Section: Resultsmentioning

confidence: 99%

Aspects of Phage-Based Vaccines for Protein and Epitope Immunization

Palma¹

2023

Vaccines

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“…El avance en otras entidades viene impulsado por su importancia veterinaria, mucho más que por su impacto en infecciones humanas. Son por ejemplo la equinococosis (29), para la que hay abundantes estudios de vacunación en perros o la fasciolosis para la que se disponen de diversos candidatos en ovejas (30) infección. Se calcula que en países en vías de desarrollo el 24,5% de los cánceres están causados por infecciones, porcentaje que se eleva al 28,5% si consideramos las zonas más pobres del continente, donde son prevalentes las NTDs (31).…”

Section: Vacunas Antihelmínticasunclassified

Vaccines and Neglected Tropical Diseases: a complicated challenge or a postpandemic hope

Diego

Manzano-Román

Muro

2022

an.ranf

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The progress of low and middle income countries is absolutely dependent on the high impact of twenty forgotten or neglected entities caused by a wide range of etiological agents. Although there are available treatments against many of them, reinfections and drug resistance hamper their control. Until now, only commercial vaccines are effective to manage for Dengue virus and rabies. Some reasons are the low efficacy of conventional vaccines, the long lasting development and the lack of industrial involvement. Moreover, the biological and structural complexity and immunomodulatory arsenal of the neglected parasitic diseases make this an important prophylactic challenge. SARS-CoV-2 pandemic showed the real potential of mRNA vaccine technology. The flexibility of the platform associated with the new and innovative technological immunoinformatic approaches offer a new hope to face many of the sanitary problems related to poverty population for the near future. Keywords: neglected tropical diseases; parasitic zoonoses; poverty; vaccines; mRNA

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