Prospective validation of clinically important changes in pain severity measured on a visual analog scale

Gallagher, E. John; Liebman, Michele; Bijur, Polly E.

doi:10.1067/mem.2001.118863

Cited by 842 publications

(571 citation statements)

References 9 publications

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“…Previous use of a 10-cm VAS in clinical studies 17,18 has shown that the minimum clinically important difference in doctor-assigned VAS is 1.8 cm or over and that patients do not perceive a change of <1.3 cm; it therefore seemed reasonable to define 1.0 cm as the limit of non-inferiority in the present study. Also, based on other studies using VAS assessments, a standard deviation of between 10% and 40% for mean VAS scores was deemed realistic.…”

Section: Discussionmentioning

confidence: 92%

“…The aim was to show that Predocol was no less effective than prednisolone, where the limits of non-inferiority were predefined according to established methodology. [17][18][19] A Predocol dose would be considered at least as efficacious as prednisolone, if the lower 95% confidence limits (CL) for the treatment difference (Predocol minus prednisolone) was not lower than minus 1.0 cm on the 10-cm VAS. An additional assessment of non-inferiority was a remission rate difference whose 95% CI did not exceed 10%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis

Rhodes

Robinson

Beales

et al. 2007

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis

Rhodes

Robinson

Beales

et al. 2007

Aliment Pharmacol Ther

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show abstract

“…The level of significance was set at p\0.05. To demonstrate the effectiveness of a treatment, a minimal clinically important difference in VAS scores for pain has been reported ranging from 0.9 to 1.4 [9,19,28] and, in DASH score, ranging from 7 to 13.5 [11,20,21]. However, other measurements do not have the reported minimal clinically significant differences.…”

Section: Surgical Techniquementioning

confidence: 99%

Is Arthroscopic Bone Graft and Fixation for Scaphoid Nonunions Effective?

Kang

Chun

Koh

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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Background Arthroscopic management of scaphoid nonunions has been advanced as a less invasive technique that allows evaluation of associated intrinsic and extrinsic ligamentous injuries; however, few studies have documented the effectiveness of arthroscopic treatment of scaphoid nonunions and which intraarticular pathologies coexist with scaphoid nonunions. Questions/purposes (1) What are the outcomes of arthroscopic management of scaphoid nonunions as assessed by the proportion of patients achieving osseous union, visual analog scale (VAS) pain score, grip strength, range of motion, Mayo Wrist Score (MWS), and Disabilities of the Arm, Shoulder and Hand (DASH) score? (2) What complications are associated with arthroscopic scaphoid nonunion management? (3) What forms of intraarticular pathology are associated with scaphoid nonunions? Methods Between 2008 and 2012, we treated 80 patients surgically for scaphoid nonunions. Of those, 45 (56%) had arthroscopic management. During that time, our general indications for using an arthroscopic approach over an open approach were symptomatic scaphoid nonunions without necrosis of the proximal fragment, severe deformities, or arthritis. Of the patients treated arthroscopically, 33 (73%) were available for followup at least 2 years later. There were five distal third, 19 middle third, and nine proximal third fractures. The mean followup was 33 months (range, 24-60 months). Union was determined by CT taken at 8 to 10 weeks after operation with bridging trabecula at nonunion site. VAS pain scores, grip strength, active flexion-extension angle, MWS, and DASH scores were obtained preoperatively and at each followup visit. The coexisting intraarticular pathologies and complications were also recorded. Results Thirty-two (97%) scaphoid nonunions healed successfully. At the last followup, the mean VAS pain score decreased (preoperative: mean 4.

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“…Several studies demonstrate that a change of 9-14 mm on a 100-mm VAS is a minimal clinically important difference in perceived pain that is reproducible among patients experiencing both mild and severe forms of pain [14][15][16][17]. When designing this study, we anticipated that 266 women would be randomized to delayed IUD insertion in the main study and return for IUD insertion.…”

Section: Statistical Analysesmentioning

confidence: 99%

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

et al. 2015

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TitleProphylactic ibuprofen does not improve pain with IUD insertion: a randomized trial. AbstractObjective: To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design: We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion.Results: A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions: Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.

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Prospective validation of clinically important changes in pain severity measured on a visual analog scale

Cited by 842 publications

References 9 publications

Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis

Clinical trial: oral prednisolone metasulfobenzoate (Predocol) vs. oral prednisolone for active ulcerative colitis

Is Arthroscopic Bone Graft and Fixation for Scaphoid Nonunions Effective?

Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial

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