Prospective surveillance of breast cancer-related lymphoedema in the first-year post-surgery: feasibility and comparison of screening measures

Blaney, Janine; McCollum, Graham; Lorimer, Jill; Bradley, J. Glenn; Kennedy, Robert J.; Rankin, Jane

doi:10.1007/s00520-014-2504-9

Cited by 31 publications

(38 citation statements)

References 38 publications

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“…The authors hypothesized this was due to the fact that some of the LE cases were localized to one region of the extremity that could not be differentiated by BIA. In the final conclusion, there was no significant correlation between CM and BIA with agreement in only 25.8% of cases . Table summarizes the studies of SFBIA compared to circumference.…”

Section: Resultsmentioning

confidence: 82%

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A comprehensive review of bioimpedance spectroscopy as a diagnostic tool for the detection and measurement of breast cancer-related lymphedema

et al. 2016

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As treatment for breast cancer improves and the threat of life-long chronic lymphedema becomes more prevalent, the need for effective screening tools emerges as crucial. This review was conducted using literature beginning in 1992 to analyze primary research testing the accuracy of bioimpedance spectroscopy as a diagnostic and early detection tool for breast cancer-related lymphedema. We concluded bioimpedance is an accurate diagnostic tool for pre-existent lymphedema, however, it has not been validated for early detection. J. Surg. Oncol. 2016;114:537-542. © 2016 Wiley Periodicals, Inc.

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Section: Resultsmentioning

confidence: 82%

“…In newer models of the machine, the impedance ratios are calculated as L‐Dex ratios. In this format, an L‐Dex score of −10 to +10 is considered normal, and a score above 10 is diagnostic for lymphedema .…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of bioimpedance spectroscopy as a diagnostic tool for the detection and measurement of breast cancer-related lymphedema

et al. 2016

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“…In their study, lymphedema was identified in 29% of patients by arm circumference and in 11% patients by bioimpedance; agreement between the two measurements for lymphedema diagnosis occurred in 25.5% of cases. 7 In contrast, Fu et al did find that bioimpedance and arm circumference were correlated in their cross-sectional study; however, their patient population differed from the aforementioned studies and notably, baseline measurements were not obtained on the study participants 4 —a limitation of their findings. Although one “best” method for lymphedema diagnosis has not reached consensus, our study results raise concerns for bioimpedance as a single tool to diagnose BCRL.…”

Section: Discussionmentioning

confidence: 80%

“…Bioimpedance has been primarily studied as a diagnostic tool for lymphedema; however, most investigators have compared bioimpedance with circumferential arm measurements, 4,6,7 which has limited reproducibility among raters. Furthermore, longitudinal prospective studies evaluating bioimpedance as a predictor of lymphedema are lacking.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Validation Study of Bioimpedance with Volume Displacement in Early-Stage Breast Cancer Patients at Risk for Lymphedema

2015

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BACKGROUND Although volume displacement (VD) is considered the gold standard for diagnosing breast cancer (BC)-related lymphedema, it is inconvenient. We compared bioimpedance (L-Dex) and VD measurements in a prospective cohort of BC patients at risk for lymphedema. METHODS Between 2010–2014, 223 BC patients were enrolled. Following exclusions (n=37), 186 received baseline VD and L-Dex; follow-up measurements were performed at 3–6 month intervals for 3 years. At each visit, patients fit into one of three categories: normal (normal VD and L-Dex); abnormal L-Dex (L-Dex>10 or increase in 10 from baseline and normal VD); or lymphedema (relative arm volume difference of >10% by VD +/− abnormal L-Dex). Change in L-Dex was plotted against change in VD; correlation was assessed using Pearson correlation. RESULTS At a median follow-up of 18.2mos, 152 patients were normal; 25 had an abnormal L-Dex; and 9 developed lymphedema without a prior L-Dex abnormality. Of 25 abnormal L-Dex patients, 4 progressed to lymphedema for a total of 13 patients with lymphedema. Evaluating all time points, 186 patients had 829 follow-up measurements. Sensitivity and specificity of L-Dex compared to VD were 75% and 93%, respectively. There was no correlation between change in VD and change in L-Dex at 3mos (R=0.31) or 6mos (R=0.21). CONCLUSIONS VD and bioimpedance demonstrated poor correlation with inconsistent overlap of measurements considered abnormal. Of patients with an abnormal L-Dex, few progressed to lymphedema; most with lymphedema did not have a prior L-Dex abnormality. Further studies are needed to understand the clinical significance of bioimpedance.

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“…Moderate to strong correlations have been reported between BIA data and both self-report ( r = 0.71, research model46) and perometry results ( r = 0.71-0.93, research model34,42,43,47; r = 0.40-0.60, clinical model48). Correlation with circumferential measurement ranged from low (clinical model)49 to moderate (0.31-0.52, research model,50 clinical model41). …”

Section: Bioimpedance Analysismentioning

confidence: 99%

Diagnosis of Upper-Quadrant Lymphedema Secondary to Cancer: Clinical Practice Guideline From the Oncology Section of APTA

Levenhagen

Davies

Perdomo

et al. 2017

Rehabilitation Oncology

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Prospective surveillance of breast cancer-related lymphoedema in the first-year post-surgery: feasibility and comparison of screening measures

Abstract: BCRL screening is acceptable and valued by breast cancer survivors. Work needs to continue to establish the most effective screening tool and the natural behaviour of BCRL within the first-year post-surgery.

Cited by 31 publications

References 38 publications

A comprehensive review of bioimpedance spectroscopy as a diagnostic tool for the detection and measurement of breast cancer-related lymphedema

A comprehensive review of bioimpedance spectroscopy as a diagnostic tool for the detection and measurement of breast cancer-related lymphedema

A Prospective Validation Study of Bioimpedance with Volume Displacement in Early-Stage Breast Cancer Patients at Risk for Lymphedema

Diagnosis of Upper-Quadrant Lymphedema Secondary to Cancer: Clinical Practice Guideline From the Oncology Section of APTA

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