Prospective study of procalcitonin as a diagnostic marker of the severity of secondary peritonitis

Trullén, Xavier Viñas; López, Rafael Rodríguez; Pi, Susana Porta; Terceros, David Salazar; Sanz, Enrique Macarulla; P, Canal; Tellez, Felix Álvarez; Castro, Concepción Iglesias; Palá, Xavier Feliu

doi:10.1016/s2173-5077(09)70067-5

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…PCT Values >10ng/ml were reported to be significant for admission to the ICU and a poor clinical prognosis. [13] In another study conducted by Nenad Ivančević et al, PCT concentrations in ninety-eight patients with acute abdominal conditions, divided into two groups namely sepsis and systemic inflammatory response syndrome (SIRs), were found to be significantly higher in the sepsis group than in the SIRs group suggesting PCT as a useful criteria for early, preoperative diagnosis of abdominal sepsis. Also, in the same study, a group of patients with abdominal symptoms lasting for more than 24 h had higher PCT levels when compared with those with symptoms lasting less than 24 h. This study shows a meaningful relationship between the severity of peritonitis and serum levels of PCT.…”

Section: Discussionmentioning

confidence: 96%

The prognostic value of Pro-Calcitonin, CRP and thyroid hormones in secondary peritonitis;A single-center prospective study

Akcay¹,

Okoh²,

Yalav³

et al. 2014

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:Infections and sepsis remain the leading cause of morbidity and mortality in secondary peritonitis. Clinicians are still challenged with the task of finding an early and reliable diagnosis of septic complications. The role of inflammatory markers (Procalcitonin (PCT), C-reactive Protein (CRP) and thyroid hormones in determining the severity of secondary peritonitis was evaluated in this study.

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Section: Discussionmentioning

confidence: 96%

The prognostic value of Pro-Calcitonin, CRP and thyroid hormones in secondary peritonitis;A single-center prospective study

Akcay¹,

Okoh²,

Yalav³

et al. 2014

Ulus Travma Acil Cerrahi Derg

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Single-blinded, randomized, and controlled clinical trial evaluating the effects of Omega-3 fatty acids among septic patients with intestinal dysfunction: A pilot study

Chen

Wang

Yun

et al. 2017

Experimental and Therapeutic Medicine

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Sepsis is a systemic inflammatory reaction, which is aggravated by aspects of the immune response that are thought to be inhibited by Omega-3 fatty acids. The aim of the present study was to determine if Omega-3 fatty acid could modulate immunological function and improve survival rate among septic patients with intestinal dysfunction. A total of 48 mechanically ventilated patients with intestinal dysfunction were included in this prospective, randomized and single-blind clinical study. Patients were randomly divided into control (group A) and treatment groups (group B). The treatment protocol for all the participants followed the Sepsis Survival Campaign guidelines, and group B received total parenteral nutrition containing 100 ml of Omega-3 fatty acids (containing 10 g refined fish oil) per day in addition to the standard treatment applied in group A. Group B had a significantly lower mortality rate compared with group A (12.5 vs. 41.7%, P<0.05) during the 28-day follow-up. Group B also had lower Acute Physiology and Chronic Health Evaluation II scores (P<0.05) and lower Marshall scores (P<0.05) at day 7. In addition, group B had a higher ratio of T helper to inducer lymphocytes as well as a higher ratio of CD4 to CD8 lymphocytes (P<0.01 for both) than group A. It was concluded that Omega-3 fatty acids improved T helper/inducer and CD4/CD8 ratios, and may have reduced mortality, among septic patients with intestinal dysfunction.

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Prospective study of procalcitonin as a diagnostic marker of the severity of secondary peritonitis

Cited by 2 publications

References 19 publications

The prognostic value of Pro-Calcitonin, CRP and thyroid hormones in secondary peritonitis;A single-center prospective study

The prognostic value of Pro-Calcitonin, CRP and thyroid hormones in secondary peritonitis;A single-center prospective study

Single-blinded, randomized, and controlled clinical trial evaluating the effects of Omega-3 fatty acids among septic patients with intestinal dysfunction: A pilot study

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