Prospective study of insomnia and incident asthma in adults: the HUNT study

Brumpton, Ben; Mai, Xiao-Mei; Laugsand, Lars Erik; Janszky, Imre; Strand, Linn Beate

doi:10.1183/13993003.01327-2016

Cited by 22 publications

(38 citation statements)

References 43 publications

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“…Similarly, another study found higher gene expression of Arntl2 (a paralog of Bmal1) and lower of Per2 in severe asthmatics when compared to mild asthmatics and healthy donors (Fajt et al 2015). This suggests a relationship These findings are supported by a recent longitudinal study that demonstrated the association of insomnia and risk of developing asthma in approximately 18,000 participants (Brumpton et al 2017).…”

Section: Asthmasupporting

confidence: 76%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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Section: Asthmasupporting

confidence: 76%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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“…Sivertsen et al 20 reported that insomnia was a significant risk factor for incidence of asthma in an 11-year large population-based prospective cohort study consisted of 24 715 participants (OR=1.47; 95% CI 1.16 to 1.86). Brumpton et al 27 also found that insomnia symptoms were associated with increased risk of incident asthma in the same population-based which consisted of 17 927 participants (three insomnia symptoms, OR=1.70; 95% CI 1.37 to 2.11). However, they used questionnaires to define insomnia and provided no information about the severity or duration of their participants’ poor sleep.…”

Section: Discussionmentioning

confidence: 87%

Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan

Lin¹,

Lai

Chien

et al. 2017

BMJ Open

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ObjectivesTo determine whether insomnia at baseline is a risk factor for new-onset asthma.MethodsWe recruited 48 871 patients with insomnia (insomnia group) newly diagnosed between 2002 and 2007, and 97 742 matched controls without insomnia (control group) from Taiwan’s Longitudinal Health Insurance Database 2000. All of the patients were followed up for 4 years to see whether new-onset asthma developed. Patients with previous asthma or insomnia were excluded. The Poisson regression was used to estimate the incidence rate ratios (IRRs) and 95% CIs of asthma. Cox proportional hazard regression was used to calculate the risk of asthma between the two groups.ResultsAfter a 4-year follow-up, 424 patients in the insomnia group and 409 in the control group developed asthma. The incidence rate of asthma was significantly higher in the insomnia group (22.01vs10.57 per 10 000 person-years). Patients with insomnia have a higher risk of developing new-onset asthma during the 4-year follow-up (HR: 2.08, 95% CI 1.82 to 2.39). The difference remained significant after adjustment (adjusted HR: 1.89, 95% CI 1.64 to 2.17).ConclusionsThis large population-based study suggests that insomnia at baseline is a risk factor for developing asthma.

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“…Conversely, designed studies have shown that asthma control is worse among patients with insomnia . It has even been proposed that insomnia symptoms may precede an asthma diagnosis and that insomnia is a risk factor for asthma . Hence, an alternative implication is that treatment of insomnia may improve asthma control.…”

Section: Discussionmentioning

confidence: 99%

Insomnia symptoms and asthma control—Interrelations and importance of comorbidities

Sundbom¹,

Malinovschi

Lindberg³

et al. 2019

Clin Experimental Allergy

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Background: Insomnia symptoms are common with asthma. The aim of the study was to analyse the associations between insomnia symptoms and asthma control, asthma severity, and asthma-related comorbidity in a community-based population.Methods: Adults (n = 23 875, ages 18-45) from the community-based LifeGene study answered a questionnaire on insomnia symptoms, airway symptoms, asthma diagnosis, asthma medication, and asthma-related comorbidities (chronic rhinosinusitis, gastro-oesophageal reflux, anxiety, depression, or obesity). Results:Of the participants, 1272 (5.3%) had asthma. The prevalence of any insomnia symptom was higher in participants with uncontrolled asthma (n = 201) than with controlled or partially controlled asthma (32.2% vs 19.9% and 20.1%, respectively, P < .01). There was no significant difference in the prevalence of insomnia symptoms between subjects with controlled asthma and subjects without asthma. Subjects with asthma and any asthma-related comorbidity reported more insomnia symptoms (29.0% vs 22.4%, P < .01) compared to asthmatics without comorbidity. Moreover, the prevalence was highest among subjects reporting both uncontrolled asthma and any asthma-related comorbidity (45.1%, P < .01). Uncontrolled asthma remained significantly associated with insomnia symptoms (OR 1.72 (1.15-2.56)) after adjusting for age, sex, BMI, smoking history, comorbidities, physical activity, and educational level, while medication level was not. Among asthma-related comorbidities, chronic rhinosinusitis (OR 1.62 (1.20-2.19)), obesity (1.87 (1.07-3.25)), and depression (OR 1.85 (1.34-2.55)) were independently associated with insomnia symptoms. Conclusion:Uncontrolled asthma was significantly associated with insomnia symptoms, while controlled or partially controlled asthma was not. Asthma-related comorbidity is of great importance, and asthma control seems to be more important than asthma severity for insomnia symptoms. K E Y W O R D Sasthma, asthma control, comorbidity, epidemiology, sleep | INTRODUC TI ONInsomnia symptoms are common in asthma. 1 One common explanation for the higher prevalence of insomnia symptoms in asthma is poor asthma control. 2,3 However, it is not fully known if this is an independent association, as several risk factors are common for insomnia and poor asthma control, and sleep quality is worse in more severe asthma. 2

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Prospective study of insomnia and incident asthma in adults: the HUNT study

Cited by 22 publications

References 43 publications

A circadian based inflammatory response – implications for respiratory disease and treatment

A circadian based inflammatory response – implications for respiratory disease and treatment

Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan

Insomnia symptoms and asthma control—Interrelations and importance of comorbidities

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