Prospective study of histopathological patterns of ovarian tumours in a tertiary care centre

Abstract

INTRODUCTIONOvarian tumours account for 3% of all cancers in females, being the second most common cancer of the female genital tract, next only to uterine cancer.1 They account for 30% of all cancers of the female genital tract.2 Ovarian tumours often go undetected and present at a later stage. This is due to their location, lack of early screening modalities and, lack of specific symptoms and signs suggestive of malignant nature. The advanced stage at presentation of ovarian cancers results in a low mean 5 year survival rate and a poor prognosis. 2 The ovarian tumours are highly heterogenous with a wide range of histologic patterns enumerated in the WHO classification. The gross appearances are useful to a certain extent in distinguishing the individual tumours, more so for the ABSTRACT Background: Ovarian tumours account for 3% of all cancers amongst women, being the second most common cancer of the female genital tract. The ovarian tumours are highly heterogenous with a wide range of histological patterns. Aim of current study was to study the histological patterns and the age incidence of the ovarian tumours in our institute. Methods:The present study is a prospective study conducted in the department of pathology, Andhra Medical College, from August 2011 to July 2013. Results: We received a total of 267 specimens of ovarian tumours during this period, out of which, 263 were primary and 4 were secondary tumours. Benign tumours were 209 (78.3%), borderline were 10 (3.7%) and malignant were 48 (18%) in numbers. Overall surface epithelial tumours constituted the majority of tumours accounting for 214 (80.2%) cases, followed by germ cell tumours 38 (14.2%) and sexcord stromal tumours 11 (4.1%). The single most common tumour diagnosed was serous cystadenoma. The most common malignant tumour was serous cystadenocarcinoma. The age groups affected ranged from 11-70 years. The peak age incidences for different histological types were as follows: surface epithelial tumours: 21-50 years, germ cell tumours: 21-30 years, sexcord stromal tumours: 51-60years. Benign tumours were more common in 21-40 years of age, borderline in 31-50 years and malignant tumours in 41-50 years age group. Conclusion:The results from our study were comparable with those reported in literature; however malignant serous and mucinous tumours showed a lower peak age incidence in our study. Krukenberg tumours also occurred in younger age group in our study.

Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India

“…Benign surface epithelial tumors were the commonest type (81.17%) followed by malignant surface epithelial tumour (15.88%) comparable to other studies 12,16,27 but with more borderline ovarian tumors 26(7.64%) similar to Mondal. 26 The suface epithelial tumours are subtyped into serous, mucinous, transitional, clear cell, endometroid types.…”

“…They are counterpart of testicular germ cell tumours. In our study they are 12.05%, consistent with other studies 15,27,35 lower than than in studies of others. 8,11,14,16,26 Mature cystic teratoma was the commonest type of germ cell tumour (80%) similar to other studies.…”

“…In our study, there were both juvenile and adult granulosa cell tumours with menstrual irregularities and postmenopausal bleeding, the incidence of was 6.47%similar to other studies. 11,15,16,20,27,36 One case of synchronous endometrial carcinoma was diagnosed, also reported in other studies. 16,27,39 .…”

“…11,15,16,20,27,36 One case of synchronous endometrial carcinoma was diagnosed, also reported in other studies. 16,27,39 . In our study there was a case of Sertolileydig cell tumour, conceived after surgery and delivered at term.…”

A study of ovarian tumors at Kathmandu medical college teaching hospital

“…4 Due to their location, lack of regular screening and lack of specific symptoms, ovarian tumour often go undetected until they attain large size and present at a later age. 5 The nature of ovarian cystic lesions is difficult to determine by clinical examination and even on surgical exploration. As the management and prognosis mainly depend on the histological type and the grade of the tumor, it is mandatory to find out the origin and the type of tumor by doing thorough histopathological examination.…”