“…Other reports have documented the use of TAI after anterior resection 35,36 or after dynamic graciloplasty, 37 and various studies have enrolled mixed patient populations, including patients with a history of abdominal surgery, idiopathic (neurogenic) bowel dysfunction, irritable bowel syndrome, anorectal malformation, coloanal anastomosis, diabetes mellitus, multiple sclerosis, SCI and neural tube closure defect. 29,32,34,38,39 Owing to the heterogeneous nature of these mixed patient populations and the low number of patients of each type, further investigation is required to confirm the efficacy of TAI in each of these settings. The potential of TAI in the treatment of the very distressing low anterior resection syndrome is of particular interest and merits further investigation, although this will need a cautious approach to avoid the possibility of perforation in this at-risk group.…”