Prospective Study Directed to the Synthesis of Symmetrical Linked Bis-Rhodanine Derivatives with Their Antimicrobial Activity

Arafa, Wael A. A.; Shaker, Raafat M.; Rabeh, Saleh A.

doi:10.3987/com-16-13479

Cited by 8 publications

(2 citation statements)

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“…Derivatives (1a-c, 1e) and (1f) were prepared following our reported methods. 30,33 All known organic products (2d), 35 (9a-c), 38,39 and (11g) 37 were confirmed by comparison of their physical and spectral data with those of authentic samples. All of the melting points of the prepared compounds were determined on an Electrothermal IA9100 apparatus (UK).…”

Section: Methodsmentioning

confidence: 77%

“…[26][27][28][29] Ultrasonic irradiation, compared with other conventional techniques, has some inherent merits, e.g., milder reaction conditions, higher yields, shorter reaction times and simpler work-ups. As part of our efforts to prepare bis-heterocyclic systems using environmentally-benign conditions, [30][31][32][33][34] we describe, herein, efficient protocols for the preparation of bis-oxazolones and bis-imidazoles driven by ultrasonic irradiation.…”

Section: Introductionmentioning

confidence: 99%

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An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

Arafa¹,

Abdel‐Magied²

2018

Arkivoc

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An efficient, straight-forward and eco-friendly synthetic strategy for the assembly of novel bisoxazolones via a four-component, sequential reaction of dialdehydes, glycine, benzoyl chloride and acetic anhydride, using ultrasound radiation, is described. Additionally, a diverse group of new bisimidazoles has been synthesized in good yields by the sonication of diamines and (Z)-4-arylidene-2-phenyloxazol-5(4H)-ones. These approaches have resulted in a number of successful routes for the facile synthesis of bis-oxazolone and bis-imidazole frameworks within minutes of irradiation. Excellent outcomes using these environmentally-friendly parameters make these synthetic schemes ideal, sustainable, green-chemistry procedures and provide simple access towards the preparation of bisheterocycles.

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Section: Methodsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

Arafa¹,

Abdel‐Magied²

2018

Arkivoc

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Synthesis and In Vitro Anticancer Evaluation of Symmetrically Bridged 1,3‐thiazine Derivatives

Malah

Ishak

Nour

et al. 2018

Journal of Heterocyclic Chem

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A series of bis‐1,3‐thiazine derivatives 3a–o were synthesized from the condensation reactions of symmetric dialdehydes 1a–c possessing aliphatic ether spacer units with 3‐substituted‐amino‐2‐cyano‐3‐mercaptoacrylamides 2a–e. The chemical structures of the products were fully characterized by using different spectroscopic techniques, such as 1H NMR, 13C NMR, IR, electron impact mass spectrometry, and elemental analysis. Compounds 3a, 3f, and 3k underwent ring opening followed by recyclization and alkylation in basic medium to afford bis‐pyrimidinones 4a–c and 5a–c. The anticancer potential of the new bis‐1,3‐thiazines was assessed in vitro against six different human cell lines, including lung A549, colon HCT116, breast MCF‐7, prostate PC3, liver HepG2, and normal melanocyte HFB4. The results revealed a potent activity of compounds 3e and 3k against breast and liver cancer cell lines in comparison with the reference drug doxorubicin with no noticeable toxicity on normal cells.

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A New Sustainable Strategy for Synthesis of Novel Series of Bis‐imidazole and Bis‐1,3‐thiazine Derivatives

Arafa

Faty

Mourad

2018

Journal of Heterocyclic Chem

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An expeditious, eco‐friendly, and efficacious protocol was achieved for the preparation of bis‐imidazoles and bis‐1,3‐thiazines from the reaction of tetracyanoethylene with dialdehydes or bis‐thiosemicarbazones, respectively. Merely mixing and sonicating the starting materials furnishes the desirable products in considerable yields. This reaction smoothly proceeded and presented many merits, over conventional and mechanochemical approaches, including simple experimental workup procedure, no by‐products, and short reaction time. Moreover, the protocol scoring admirably in various green metrics, as a consequence, shows these approaches to be an ideal sustainable and green process.

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Prospective Study Directed to the Synthesis of Symmetrical Linked Bis-Rhodanine Derivatives with Their Antimicrobial Activity

Cited by 8 publications

References 0 publications

An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

An eco-compatible access to diversified bisoxazolone and bisimidazole derivatives

Synthesis and In Vitro Anticancer Evaluation of Symmetrically Bridged 1,3‐thiazine Derivatives

A New Sustainable Strategy for Synthesis of Novel Series of Bis‐imidazole and Bis‐1,3‐thiazine Derivatives

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