Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer

Simon, Charles; Vladimirov, Iavor K.; Cortes, G.; Ortega, Israel; Cabanillas, Sergio; Vidal, C.; Gilés, Juan; Izquierdo, Alexandra; Portela, Susana; Fernández, I.; Ferrando, Marcos; Mackens, Shari; Barrera, Saúl; Pellicer, A.

doi:10.1016/j.fertnstert.2016.07.144

Cited by 20 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improved IVF outcome in RIF cases after pET was well-documented in many retrospective studies,[23] but Simon et al . [16] by their prospective randomized study has proved its role even in the women who is going for their first IVF cycle. He proved that after pET (based on ERA test results), PRs and OPRs (85.7% and 55.1%) were significantly higher as compared with fresh embryo transfer (61.7% and 43.3%) or deferred embryo transfer (60.8% and 44.6%) without ERA.…”

Section: Discussionmentioning

confidence: 99%

Personalized embryo transfer helps in improving In vitro fertilization/ICSI outcomes in patients with recurrent implantation failure

Patel¹,

Patel²,

Banker

et al. 2019

J Hum Reprod Sci

View full text Add to dashboard Cite

Aims: This study aims to compare clinical outcomes in patients of recurrent implantation failure (RIF), who had embryo transfer (ET) following a receptive (R) endometrial receptivity array (ERA) and a personalized embryo transfer (pET) after a nonreceptive (NR) ERA. Settings and Design: This was a retrospective observational study. Study Period: July 2013–September 2017. Subjects and Methods: Two hundred and forty-eight patients having unexplained RIF who underwent ERA test were included in the study. Clinical outcomes were compared between patients having a receptive (R) ERA and those having a NR ERA who underwent a pET-based on ERA. Statistical Analysis Used: Chi-square and t -test. Results: ERA predicted receptive (R) endometrium at P + 5 in 82.3% (204/248) patients and NR in 17.7% (44/248) patients. Average failed previous in vitro fertilization cycles were 3.67 ± 1.67 among receptive ERA patients and 4.09 ± 1.68 among NR ERA patients. Pregnancy rate (PR), clinical PR, implantation rate (IR), abortion rate (AR), ongoing pregnancy rate (OPR), and cumulative PR were comparable between patients having receptive ERA who had a routine Embryo Transfer (ET) and those with an NR ERA who underwent a pET. Conclusions: ERA is helpful in identifying the window of implantation (WOI) through genetic expressions of the endometrium to pinpoint embryo transfer timing. pET guided by ERA in patients of RIF with displaced WOI improves IRs and OPRs.

show abstract

Section: Discussionmentioning

confidence: 99%

Personalized embryo transfer helps in improving In vitro fertilization/ICSI outcomes in patients with recurrent implantation failure

Patel¹,

Patel²,

Banker

et al. 2019

J Hum Reprod Sci

View full text Add to dashboard Cite

show abstract

“…This prospective multicenter trial investigates differences in implantation, pregnancy, ongoing pregnancy rates, and delivery among women having blastocyst transfer in their first IVF cycle. Patients were randomized to fresh cycles, deferred ET, or pET, and data from the interim study demonstrate a significant increase in pregnancy rates of 25% in the pET group versus the other two, an increase in ongoing pregnancy rates of 11% (P¼ .24), and implantation rates of 12% and 6.4% higher versus fresh and deferred ET, respectively (P¼ .21) (42). Patient recruitment is complete, and final results in terms of live-birth rates will be obtained and published within a year to determine the utility of this endometrial diagnostic intervention in reproductive care.…”

Section: Does Rif Reflect Endometrial Dysfunction or Simply Desynchronization Between The Developing Embryo And The Receptive Endometriummentioning

confidence: 99%

Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium

Valdés

Schutt

Simón

2017

Fertility and Sterility

119

View full text Add to dashboard Cite

Repeated implantation failure (RIF) is an intriguing, massive failure of reproductive treatment in otherwise healthy women leading to the introduction of empirical adjuvant interventions that are costly, inefficient, and frustrating for our patients. In this article, we will try to convince the readers that RIF is neither a stigma nor a mysterious pathology but rather our failure to diagnose and properly synchronize the euploid blastocyst with the patient's personalized window of implantation.

show abstract

“…This indicates that not only couples suffering from implantation failure but also couples that experience miscarriage could have a displaced WOI and could benefit from the synchronization of embryo transfer with its WOI. This influence of a deviation of hours may be the reason why some studies of personalised embryo transfer (pET) detect an unexpectedly high number of clinical miscarriages 29 . In the recent RCT by ERA, intention to treat analysis revealed 3 times more clinical miscarriages in the pET group compared to the fresh embryo transfer group 20 .…”

Section: Discussionmentioning

confidence: 99%

The precise determination of the window of implantation significantly improves ART outcomes

Enciso¹,

Aizpurúa

Rodríguez-Estrada³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The human endometrium is receptive to the embryo for a specific period of time known as the window of implantation (WOI). During this period, the endometrium shows a specific gene expression profile suitable for endometrial function evaluation. ER Map is a molecular tool able to accurately predict endometrial receptivity status by transcriptomic analysis. In this retrospective study, including 2256 subfertile patients undergoing ART treatment, the clinical value of precise WOI determination is studied in detail. Results obtained when single embryo transfers (sET) were scheduled either within the WOI timeframe as established by ER Map, or deviating from this WOI, are assessed and compared. Data obtained showed that 34.18% (771/2256) of patients had a displaced WOI. Analysis of ART outcomes showed significantly higher pregnancy rates in transfers scheduled within the WOI predicted compared to transfers that deviated more than 12h from this WOI (44.35% vs 23.08%, p < 0.001). The deviation from the WOI had also an impact on the progression of pregnancy, with a significant increase in pregnancy loss (~ twofold) observed in transfers that deviated more than 12h from the WOI predicted. These results indicate that the precise determination of the WOI and personalised embryo transfer can significantly improve clinical outcomes.

show abstract

Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer

Cited by 20 publications

References 0 publications

Personalized embryo transfer helps in improving In vitro fertilization/ICSI outcomes in patients with recurrent implantation failure

Personalized embryo transfer helps in improving In vitro fertilization/ICSI outcomes in patients with recurrent implantation failure

Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium

The precise determination of the window of implantation significantly improves ART outcomes

Contact Info

Product

Resources

About