Prospective randomised comparison of dilation (high compliance balloon) VS. Botulinum toxin injection (BTX) in esophageal achalasia

Nebendahl, C; Brand, B; Schrenck, T. von; Matsui, U.; Thonke, Frank; Bohnacker, Sabine; Seitz, U; Kf, Binmoeller; Soehendra, Nib

doi:10.1016/s0016-5085(98)80977-3

Cited by 1 publication

(2 citation statements)

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“…Table 2 reports the data from all 19 articles published in international journals according to the Medline database, 12 57, 59-76 and 12 Table 3 reports the data from 19 abstracts published in Gastroenterology and the American Journal of Gastroenterology between 1995 and 2002. 13 58,[77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] Of these publications, 12…”

Section: Achalasiamentioning

confidence: 99%

“…Table 2 reports the data from all 19 articles published in international journals according to the Medline database, 57 , 59–76 and Table 3 reports the data from 19 abstracts published in Gastroenterology and the American Journal of Gastroenterology between 1995 and 2002 58 ,. 77–94 Of these publications, 12 compare Btx‐A with dilation therapy (one also compares it with surgical therapy) and one studies the combination of Btx‐A and pneumatic dilation. The Btx‐A doses employed vary from 50 to 200 U, but most frequently each quadrant of the lower oesophageal sphincter receives an injection of 20–25 U, for a total dose of 80–100 U.…”

Section: Botulinum Toxin Therapy In Achalasiamentioning

confidence: 99%

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Botulinum toxin in the therapy of gastrointestinal motility disorders

Gui

Rossi

Runfola

et al. 2003

Aliment Pharmacol Ther

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Summary Since 1980, botulinum toxin has been employed for the treatment of various voluntary muscle spastic disorders in the fields of neurology and ophthalmology. More recently, botulinum toxin has been proved to be effective in the therapy of dyskinetic smooth muscle disorders of the gastrointestinal tract. Achalasia and anal fissure are the gastrointestinal disorders in which botulinum toxin therapy has been most extensively investigated. Botulinum toxin is the best treatment option for achalasia in patients whose condition makes them unfit for pneumatic dilation or surgery. In anal fissure, botulinum toxin is highly effective and may become the treatment of choice. In the future, botulinum toxin application in the gastrointestinal tract will be extended to many other gastrointestinal disorders, such as non‐achalasic motor disorders of the oesophagus, dysfunction of Oddi's sphincter, achalasia of the internal anal sphincter and others. This article describes the mechanism of action, rationale of employment, indications and side‐effects of botulinum toxin application in smooth muscle disorders of the gastrointestinal tract, and compares the results of different techniques of botulinum toxin therapeutic application.

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