Prospective evaluation of the prognostic scores for cirrhotic patients admitted to an Intensive Care Unit

Levesque, Éric; Hoti, Emir; Azoulay, Daniel; Ichaı̈, Philippe; Habouchi, Houssam; Castaing, Denis; Samuel, Didier; Saliba, Faouzi

doi:10.1016/j.jhep.2011.06.024

Cited by 177 publications

(178 citation statements)

References 44 publications

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“…1). Similar to the study evaluating the outcome in the ICU of patients with cirrhosis, 6 we found that liver function was not the main determinant of outcome so that an organ failure score as the SOFA or the new chronic liver failure (CLIF)-SOFA score 7 could be more useful in predicting outcome, although not sufficient.…”

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confidence: 52%

Liver transplantation in patients with end‐stage liver disease requiring intensive care unit admission and intubation

et al. 2015

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supporting

confidence: 52%

Liver transplantation in patients with end‐stage liver disease requiring intensive care unit admission and intubation

et al. 2015

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“…Since the original paper, SOFA and modifications of SOFA have been used to prognosticate critically ill patients with liver cirrhosis and liver failure [108,109]. Moreau and colleagues primarily used the chronic liver failuresequential organ failure assessment (CLIF-SOFA) score to identify diagnostic criteria of ACLF in European patients with acute hepatic decompensation [2].…”

Section: Prognostic Scores For Aclfmentioning

confidence: 99%

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014

et al. 2014

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The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. Due to the rapid advancements in the knowledge and available information, a consortium of members from countries across Asia Pacific, ''APASL ACLF Research Consortium (AARC),'' was formed in 2012. A large cohort of retrospective and prospective data of ACLF patients was collated and followed up in this data base. The current ACLF definition was reassessed based on the new AARC data base. These initiatives were concluded on a 2-day meeting in February 2014 at New Delhi and led to the development of the final AARC consensus. Only those statements which were based on the evidence and were unanimously recommended were accepted. These statements were circulated again to all the experts and subsequently presented at the annual conference of the APASL at Brisbane, on March 14, 2014. The suggestions from the delegates were analyzed by the expert panel, and the modifications in the consensus were made. The final consensus and guidelines document was prepared. After detailed deliberations and data analysis, the

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“…Most studies have shown that SOFA scores correlate with mortality better than MELD scores [31][32][33][34][35][36][37][38] , APACHE II scores 31,32,34,[38][39][40][41] , and SAPS II scores. 37 Das et al reported the presence of five non-hematologic organ failures in the SOFA score at the admission to the ICU was associated with 100% in-hospital mortality. 33 Moreover, the accuracy of SOFA scores was improved when reassessed at 48 to 72 hours after the admission to the ICU.…”

Section: Comparing Meld Score and Icu-specific Scores (Saps II Apachmentioning

confidence: 99%

“…44 Validation of the score was confirmed with external single center prospective cohort study of ACLF patients admitted to the ICU. 37 Jalan et al reported that CLIF-C ACLF score correlates with mortality better than the MELD score, MELD-Na score, CTP score, and CLIF-SOFA score in patients with ACLF. 44 Sequential use of the score also improves the predictive performance and should be considered as a good prognostic predictor for cirrhotic patients.…”

Section: Comparing Meld Score and Icu-specific Scores (Saps II Apachmentioning

confidence: 99%

The use of MELD scores in critically ill cirrhotic patients

Rassameehiran¹,

Woreta²

2016

SWRCCC

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The Model for End-Stage Liver Disease (MELD) was originally created to predict survival following transjugular intrahepatic portosystemic shunt and was subsequently found to accurately predict mortality in patients with end-stage liver disease. It has been used in the United States for liver allocation since 2002, and implementation of the MELD score resulted in a reduction in total number of deaths on the waitlist and a reduction in waiting time. Critically ill cirrhotic patients have an in-hospital mortality greater than 50%. Although the MELD score was also found to be an accurate predictor of in-ICU mortality and in-hospital mortality after ICU admission in critically ill cirrhotic patients, the Sequential Organ Failure Assessment (SOFA) score appears to perform better in many studies. The Chronic Liver Failure Consortium Acute-onChronic Liver Failure (CLIF-C ACLF) score was later developed by using specific cut-points for each organ failure score system in CLIF patients to predict mortality in patients with ACLF. Neither the MELD nor SOFA score independently predicts post-liver transplantation mortality in cirrhotic patients with extrahepatic organ failure and should not be use as a delisting criterion for these patients. More data are needed to determine the accuracy of the CLIF-C ACLF score in predicting post-liver transplantation outcomes. Prospective evaluation of critically ill cirrhotic patients is needed to optimize liver organ allocation.

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Prospective evaluation of the prognostic scores for cirrhotic patients admitted to an Intensive Care Unit

Cited by 177 publications

References 44 publications

Liver transplantation in patients with end‐stage liver disease requiring intensive care unit admission and intubation

Liver transplantation in patients with end‐stage liver disease requiring intensive care unit admission and intubation

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014

The use of MELD scores in critically ill cirrhotic patients

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