Prospective comparative study of the efficacy of celsior solution for preservation in clinical liver transplant

Díaz, Juan Carlos Meneu; Vicente, Emilio; Nuño, Javier; Quijano, Yolanda; López-Hervás, P; Bárcena, Rafael; Honrubia, A.; Sánchez, Santiago Díaz; Rodríguez, Gloria

doi:10.1016/s0041-1345(01)02661-6

Cited by 13 publications

(9 citation statements)

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“…Other endpoints were similar to those recorded elsewhere with Celsior solution. The rate of primary dysfunction in our patients was 1.4%, within the range of 0–2.4% observed by previous authors (18–23). Reports in the literature have described comparable recovery of liver function with Celsior or UW solution (18, 19, 21), the exception being Pedotti et al.…”

Section: Discussionsupporting

confidence: 89%

“…The rate of primary dysfunction in our patients was 1.4%, within the range of 0–2.4% observed by previous authors (18–23). Reports in the literature have described comparable recovery of liver function with Celsior or UW solution (18, 19, 21), the exception being Pedotti et al. who noted that biliary stasis indices showed a trend to more rapid recovery in the Celsior cohort, with the difference reaching significance for total bilirubin at day 5 (20).…”

Section: Discussionsupporting

confidence: 89%

“…Previously, four prospective (18–21) studies and one retrospective (22) study have compared outcomes with Celsior or UW solution in human recipients. In contrast to these trials, the current study included a non‐selected donor pool.…”

Section: Discussionmentioning

confidence: 99%

“…We included donor grafts regardless of steatosis severity and hemodynamic instability. In other prospective or retrospective studies, at least one category was excluded or information was unavailable (18–22). Our findings, however, are entirely consistent with previous reports from more selected donor populations (19, 20, 22), suggesting that the similarity of graft outcomes observed with either Celsior or UW solution in high quality donor livers is maintained with a more mixed donor pool.…”

Section: Discussionmentioning

confidence: 99%

“…commented, however, that the difference may not have been due to choice of preservation solution, as the most relevant complications included two biliary fistulas, three cases of intraperitoneal bleeding and four cases of hepatic artery thrombosis, events that they would not have expected to result from differences in preservation fluids. Hepatic artery thrombosis has been reported in between 0–4% of liver transplant recipients following graft preservation with Celsior (18, 19, 23). Although a direct relation between artery stenosis or thrombosis and preservation solution has never been demonstrated, it could be suggested that endothelial destruction is involved in the occurrence of stenosis and subsequent thrombosis of the hepatic artery.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and safety of Celsior preservation fluid in liver transplantation: one‐year follow up of a prospective, multicenter, non‐randomized study

Boudjéma¹,

Grandadam²,

Compagnon³

et al. 2011

Clinical Transplantation

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The purpose of this prospective, nine-center, non-randomized study was to assess the efficacy and safety of Celsior preservation fluid in liver transplantation using unselected donors. As data comparing allograft outcomes following liver transplantation using Celsior and University of Wisconsin (UW) preservation fluids are limited, we also compared our cohort with matched controls selected from the European Liver Transplant Registry (ELTR) who received total liver grafts preserved with UW solution during the same period. One hundred and forty patients who received livers preserved with Celsior were included. The primary endpoint, graft loss at one-yr post-transplantation, was observed in 24 patients (17.1%) which was not significantly different from the 20.0% pre-defined threshold rate (95% confidence interval [CI] 10.9, 23.4; p=0.398). Predictive factors for graft loss on univariate analysis were moderate-to-severe steatosis on the donor graft (5/22 patients with graft loss vs. 8/107 patients without, p=0.046) and duration of warm ischemia (1.4±1.1 h in patients with graft loss vs. 0.9±0.5 h in patients without, p=0.034). Hepatic artery thrombosis and stenosis occurred in seven (5.0%) and six (4.3%) patients, respectively. The comparison of our patients to 420 ELTR controls showed that one-yr graft survival rates (Celsior: 82.9%, 95% CI 75.8, 88.2; UW: 78.6%, 95% CI 74.4, 82.2) and Kaplan-Meier one-yr graft survival distributions (p=0.285) were similar. Within the cold ischemia time achieved in our study, liver preservation with Celsior appeared efficient and safe. Comparison with ELTR patients suggested that liver allograft survival was similar using Celsior or UW solution for preservation of unselected donor grafts.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Efficacy and safety of Celsior preservation fluid in liver transplantation: one‐year follow up of a prospective, multicenter, non‐randomized study

Boudjéma¹,

Grandadam²,

Compagnon³

et al. 2011

Clinical Transplantation

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Comparative prospective study of two liver graft preservation solutions: University of Wisconsin and Celsior

López‐Andújar¹,

Deusa²,

Montalvá³

et al. 2009

Liver Transpl

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University of Wisconsin solution (UWS) is the gold standard for graft preservation. Celsior solution (CS) is a new solution not as yet widely used in liver grafts. The aim of this study was to compare the liver function of transplanted grafts stored in these 2 preservation solutions. The primary endpoints were the rates of primary nonfunction (PNF) and primary dysfunction (PDF). We performed a prospective and pseudorandomized study that included 196 patients (representing 104 and 92 livers preserved in UWS and CS, respectively) at La Fe University Hospital (Valencia, Spain) between March 2003 and May 2005. PNF and PDF rates, liver function laboratory parameters, postoperative bleeding, vascular and biliary complications, and patient and graft survival at 3 years were compared for the 2 groups. The 2 groups were similar in terms of donor variables, recipient variables, and surgical techniques. The PNF rates were 2.2% and 1.9% in the CS and UWS groups, respectively (P ϭ not significant), and the PDF rates were 15.2% and 15.5% in the CS and UWS groups, respectively (P ϭ not significant). There were no significant differences in the laboratory parameters for the 2 groups, except for alanine aminotransferase levels in month 3, which were lower in the CS group (P ϭ 0.01). No significant differences were observed in terms of complications. Three-year patient and graft survival rates were as follows for years 1, 2, and 3: 83%, 80%, and 76% (patient) and 80%, 77%, and 73% (graft) for the UWS group and 83%, 77%, and 70% (patient) and 81%, 73%, and 67% (graft) for the CS group (P ϭ not significant). In conclusion, this study shows that CS is as effective as UWS in liver preservation.

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Pancreas preservation with university of wisconsin and celsior solutions

Boggi

Coletti

Vistoli

et al. 2004

Transplantation Proceedings

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Prospective comparative study of the efficacy of celsior solution for preservation in clinical liver transplant

Cited by 13 publications

References 1 publication

Efficacy and safety of Celsior preservation fluid in liver transplantation: one‐year follow up of a prospective, multicenter, non‐randomized study

Efficacy and safety of Celsior preservation fluid in liver transplantation: one‐year follow up of a prospective, multicenter, non‐randomized study

Comparative prospective study of two liver graft preservation solutions: University of Wisconsin and Celsior

Pancreas preservation with university of wisconsin and celsior solutions

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