Prosopagnosia can be associated with damage confined to the right hemisphere—An MRI and PET study and a review of the literature

Renzi, Ennio De; Perani, Daniela; Carlesimo, Giovanni Augusto; Silveri, Maria Caterina; Fazio, Ferruccio

doi:10.1016/0028-3932(94)90041-8

Cited by 312 publications

(178 citation statements)

References 19 publications

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“…In addition, deficits in the recognition of familiar faces (prosopagnosia) are another feature typically reported in cases of PCA [40,48] and has been linked to damage of the right temporal lobe [13,15,27]. Symptoms of prosopagnosia were present in 24% of our PCA cohort.…”

Section: Discussionmentioning

confidence: 71%

Imaging correlates of posterior cortical atrophy

Whitwell

Jack

Kantarci

et al. 2007

Neurobiology of Aging

184

143

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The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in subjects with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 subjects with PCA, 38 subjects with typical AD, and 38 controls. Clinical data was assessed in all PCA subjects. Single-voxel 1 H MRS located in the posterior cingulate was analyzed in a subset of subjects with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Subjects with PCA showed greater atrophy in the right visual association cortex than subjects with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1 H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

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Section: Discussionmentioning

confidence: 71%

Imaging correlates of posterior cortical atrophy

Whitwell

Jack

Kantarci

et al. 2007

Neurobiology of Aging

184

143

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“…The observation that all four patients exhibited left visual field deficits and some degree of prosopagnosia (which is commonly associated with right-sided lesions; De Renzi et al, 1994), highlights that even in the two cases of bilateral lesions, the right hemisphere was predominantly impaired. The localization of visual-emotional integration to the right hemisphere is also supported by existing research.…”

Section: Discussionmentioning

confidence: 85%

Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration

Fischer

Perez

Prasad³

et al. 2016

Social Cognitive and Affective Neuroscience

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The mechanism by which the brain integrates visual and emotional information remains incompletely understood, and can be studied through focal lesions that selectively disrupt this process. To date, three reported cases of visual hypoemotionality, a vision-specific form of derealization, have resulted from lesions of the temporo-occipital junction. We present a fourth case of this rare phenomenon, and investigate the role of the inferior longitudinal fasciculus (ILF) in the underlying pathophysiology. A 50-year-old right-handed male was found to have a right medial temporal lobe tumor following new-onset seizures. Interstitial laser ablation of the lesion was complicated by a right temporo-parieto-occipital intraparenchymal hemorrhage. The patient subsequently experienced emotional estrangement from visual stimuli. A lesion overlap analysis was conducted to assess involvement of the ILF by this patient's lesion and those of the three previously described cases, and diffusion tensor imaging was acquired in our case to further investigate ILF disruption. All four lesions specifically overlapped with the expected trajectory of the right ILF, and diminished structural integrity of the right ILF was observed in our case. These findings implicate the ILF in visual hypoemotionality, suggesting that the ILF is critical for integrating visual information with its emotional content.

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“…Lesion studies and functional imaging data converge in indicating that the fusiform gyrus is the primary site of face perception (De Renzi et al, 1994;Gorno-Tempini et al, 1998;Kanwisher et al, 1997). Converging evidence indicates that multimodal person-specific semantic information is processed in the antero-lateral temporal lobe.…”

Section: Discussionmentioning

confidence: 99%

Cognitive and Behavioral Profile in a Case of Right Anterior Temporal Lobe Neurodegeneration

Gorno‐Tempini

Rankin

Woolley

et al. 2004

Cortex

155

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INTRODUCTIONSemantic dementia (SD) is a clinical syndrome characterized by a progressive loss of conceptual knowledge. Patients typically present in the presenium with difficulty in recalling and understanding words, and later show impairment in recognizing objects (Lambon Ralph et al., 1998Hodges et al., 1992). Surface dyslexia is also part of the SD clinical picture, as patients have greater difficulty reading words with irregular pronunciations (such as "yacht") compared to regularly spelled words (such as "context"). Within the language domain, speech, phonological and syntactic processing are usually spared. Spatial abilities, non-verbal reasoning and day-to-day episodic memory also remain relatively intact, while episodic memory is often impaired on formal testing (see Hodges and Miller, 2001). Current clinical research criteria list SD as one of the possible clinical presentations of frontotemporal lobar degeneration (FTLD) (Neary et al., 1998). Neuroimaging findings in SD indicate that the anterior temporal lobe is the site of most prominent atrophy and/or hypometabolism, providing a powerful model for studying this brain region rarely hit by other neurological diseases (Mummery et al., 2000;Galton et al., 2001;Chan et al., 2001;Rosen et al., 2002a). Voxel-based Morphometry studies (VBM) and region of interest analysis on MRI scans have shown that the hippocampal/amygdala structures and the infero-lateral temporal neocortex are both significantly atrophied in SD (Chan et al., 2001;Rosen et al., 2002aRosen et al., , 2002b. It has also been shown that the ventro-medial frontal lobe and the insula are involved (Rosen et al., 2002a). The finding that orbitofrontal cortex and amygdala are damaged in SD is consistent with reports that personality changes, disturbances in social behavior, and abnormalities in emotional processing can be part of the clinical syndrome.Most reported cases of semantic dementia have shown mainly left anterior temporal lobe atrophy. Thus, the classic clinical picture of SD with prominent semantic memory deficits has also been labeled as the "left temporal lobe variant"(LTLV) of FTLD (Edwards-Lee et al., 1997). Less evidence is available regarding the clinical presentation of cases with "right-temporal lobe variant" (RTLV) of FTLD. Only a few reports of RTLV cases have concentrated on describing early difficulties in processing information regarding familiar people, either as progressive disturbance in recognizing familiar faces, or as a more generalized semantic deficit for person-specific information (Gainotti et al., 2003;Barbarotto et al., 1995;Gentileschi et al., 1999;Tyrrell et al., 1990;Evans et al., 1995). In these cases, the presence of behavioral changes was sometimes mentioned, but its significance and the time of first manifestation was not reported (Gainotti et al., 2003 ABSTRACT Semantic dementia (SD) is a clinical variant of frontotemporal lobar degeneration (FTLD) characterized by progressive deterioration of semantic memory with relative sparing of other cognitive fun...

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Prosopagnosia can be associated with damage confined to the right hemisphere—An MRI and PET study and a review of the literature

Cited by 312 publications

References 19 publications

Imaging correlates of posterior cortical atrophy

Imaging correlates of posterior cortical atrophy

Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration

Cognitive and Behavioral Profile in a Case of Right Anterior Temporal Lobe Neurodegeneration

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