2017
DOI: 10.1111/mmi.13679
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ProQ/FinO‐domain proteins: another ubiquitous family of RNA matchmakers?

Abstract: Summary Small RNAs (sRNAs), particularly those that act by limited base pairing with mRNAs, are part of most regulatory networks in bacteria. In many cases, the base-pairing interaction is facilitated by the RNA chaperone Hfq. However, not all bacteria encode Hfq and some base-pairing sRNAs do not require Hfq raising the possibility of other RNA chaperones. Candidates are proteins with homology to FinO, a factor that promotes base pairing between the FinP antisense sRNA and the traJ mRNA to control F plasmid t… Show more

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Cited by 121 publications
(121 citation statements)
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“…This chapter, however, will focus on RNA binding proteins that “passively” remodel RNA structures without hydrolyzing ATP. In bacteria, this type of passive RNA chaperone includes cold shock proteins (CSPs) (14), the Sm family protein Hfq (21), the FinO/ProQ family of RNA binding proteins (22), and ribosomal proteins S1 (2325) and S12 (26). H-NS and StpA, which interact with the bacterial nucleoid, also possess RNA chaperone activity (17).…”
Section: Introductionmentioning
confidence: 99%
“…This chapter, however, will focus on RNA binding proteins that “passively” remodel RNA structures without hydrolyzing ATP. In bacteria, this type of passive RNA chaperone includes cold shock proteins (CSPs) (14), the Sm family protein Hfq (21), the FinO/ProQ family of RNA binding proteins (22), and ribosomal proteins S1 (2325) and S12 (26). H-NS and StpA, which interact with the bacterial nucleoid, also possess RNA chaperone activity (17).…”
Section: Introductionmentioning
confidence: 99%
“…The genes involved in the catalase (AT730_23560) and superoxide dismutase (AT730_10000), GSH‐dependent defence system, chaperones and stress response are up‐regulated by oxidative stress (Table ), since they can directly clear the ROS or decrease the effect of oxidative stress (Devasagayam, Sundquist, Di Mascio, Kaiser, & Sies, ; Li, Hein, Zou, & Klug, ). The gene AT730_03510 encoding the RNA chaperone ProQ, which has an important function on post‐transcriptional regulation (Olejniczak & Storz, ), was increased. Interestingly, some genes related to iron transport were down regulated, while the other similar genes were up regulated (Table ).…”
Section: Resultsmentioning
confidence: 99%
“…In contrast, expression of functional sRNAs may be more dependent on RNA chaperones and/or processing factors, as well as cis‐acting sequence elements at their transcriptional boundaries that are difficult to define at (Chae et al, ; Moores et al, ; Morita et al, ; Kriner, Sevostyanova, & Groisman, ; Shiflett et al, ). Although RNA chaperones have yet to be identified in mycobacteria, the roles of extended native 3′ sequences for expression of mycobacterial sRNAs warrant further investigation to determine whether mcr11 is exceptional or representative of a larger group of sRNAs with regards to expression and stability requirements (Ishikawa, Otaka, Maki, Morita, & Aiba, ; Johnson et al, ; Moores et al, ; Regnier & Hajnsdorf, ; Sauer & Weichenrieder, ; Shiflett et al, ; Olejniczak & Storz, ).…”
Section: Discussionmentioning
confidence: 99%
“…Although RNA chaperones have yet to be identified in mycobacteria, the roles of extended native 3′ sequences for expression of mycobacterial sRNAs warrant further investigation to determine whether mcr11 is exceptional or representative of a larger group of sRNAs with regards to expression and stability requirements (Ishikawa, Otaka, Maki, Morita, & Aiba, 2012;Johnson et al, 2014;Moores et al, 2017;Regnier & Hajnsdorf, 2013;Sauer & Weichenrieder, 2011;Shiflett et al, 2003;Olejniczak & Storz, 2017).…”
Section: Mechanism Of Mcr11 Transcriptional Terminationmentioning
confidence: 99%