Propranolol Therapy for Hemorrhagic Lymphangioma of the Tongue

Propranolol as an Alternative Treatment Option for Pediatric Lymphatic Malformation

“…Similar observations have been reported in patients with lingual LM lesions (Leboulanger et al 2011). Beta blockers inhibit the vasodilation mediated by adrenaline via beta-adrenergic receptors, and this leads to vasoconstriction.…”

Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol

“…Propranolol is a potential alternative treatment for lymphangioma . However, propranolol did not reduce tumor volume but effectively controlled bleeding in patients with tongue lymphangiomas.…”

Propranolol for the Treatment of Lymphatic Malformations in a Neonate – A Case Report and Review of Literature

“…Variable degrees of efficacy were seen in a variety of lymphatic anomalies, but most patients had clinical improvement within the first few days to a month of therapy. 47,64,[67][68][69][70][71][72] Two prior case reports in premature patients presenting with hydrops fetalis and chylothorax due to suspected lymphangiectasia have also shown treatment success with propranolol. Response was seen within the first 1 to 2 weeks, and extubation was facilitated in both patients.…”

“…Dosing in term neonates, infants, and pediatric patients has ranged from 1 to 4 mg/kg/day, with most patients receiving 1 to 2 mg/kg/day divided. 47,64,[67][68][69][70][71][72] Case reports in premature neonates used lower starting dosages, 0.1 mg/kg/day and 0.5 mg/kg/day, and both patients were titrated to a max dose of 2 mg/kg/ day. 56,65 We reported an analogous time-coincident clinical improvement in our patient of a similar gestational age and presentation.…”