Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases

Abstract

In this paper the Working Group on Myocardial and Pericardial Disease proposes a revised definition of dilated cardiomyopathy (DCM) in an attempt to bridge the gap between our recent understanding of the disease spectrum and its clinical presentation in relatives, which is key for early diagnosis and the institution of potential preventative measures. We also provide practical hints to identify subsets of the DCM syndrome where aetiology directed management has great clinical relevance.

Pediatric cardiomyopathies: A review of literature on clinical status and meta-analysis of diagnosis and clinical management methods

“…Although a large number of early studies investigated the natural history of cardiomyopathies in infants and children, they only offered fragmentary evidence on the incidence of pediatric cardiomyopathies [8][9][10][11][12][13][14][15][16][17][18][19]. The main limitation of these early studies was small or ethnically homogenous samples limiting statistical support of findings to other excluded pediatric populations [2].…”

“…Left ventricular (LV) or bi-ventricular dilatation and global systolic dysfunction in the absence of abnormal loading conditions (such as hypertension or valvular disorders) or coronary artery disease (CAD) [8] Hypertrophic…”

Reversible Dilated Cardiomyopathy: Into the Thaumaturgy of the Heart—Part 1

“…1 Examples are: thiamine deficiency (Beri-Beri), zinc and copper deficiency (as possible contributors to DCM), selenium deficiency, carnitine deficiency (especially in pediatric population); hypo-and hyper-thyroidism, Cushing or Addison disease, phaeocromocytoma, acromegaly, diabetes mellitus, iron overload (secondary to transfusions or hemochromatosis). It is therefore of paramount importance to recognize these unbalances with specific tests as correcting them in timely fashion may completely reverse LV systolic dysfunction.…”

“…1 In the acquired forms of the disease, if the pathogenic agent is persistent, undiagnosed or untreated, permanent ultrastructural and morphological changes may lead to irreversible dysfunction. Conversely, when DCM is promptly recognized and treated, the heart may show an extraordinary ability to recover from left ventricular (LV) systolic dysfunction.…”

Modern View on Cardiotoxicity of Chemotherapeutics in Oncology Including Anthracyclines

“…В то время как основными "классическими" при-чинами хронической сердечной недостаточности (ХСН) являются ишемическая болезнь сердца (постинфарктный кардиосклероз, хроническая постинфарктная аневризма), артериальная гиперто-ния и их сочетание, кардиомиопатии (КМП, чаще всего дилатационная) и миокардит, все чаще в раз-личных рекомендациях по диагностике и лечению сердечной недостаточности (СН) говорится о токси-ческих и лучевых воздействиях на миокард в качестве ее этиологического фактора [1][2][3].…”