Proposal for a microcosm biofilm model for the study of vulvovaginal candidiasis

Cordeiro, Rossana de Aguiar; Andrade, Ana Raquel Colares de; Portela, Fernando Victor Monteiro; Pereira, Lívia Maria Galdino; Moura, Santiago Gonçalves Bezerra; Sampaio, Mônica Dantas; Pereira, Estefania Mota Araripe; Guedes, Gláucia Morgana de Melo; Bandeira, Silviane Praciano; Lima-Neto, Reginaldo Gonçalves de; Melo, Vânia Maria Maciel; Brilhante, Raimunda Sâmia Nogueira; Castelo‐Branco, Débora Souza Collares Maia; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa

doi:10.1080/08927014.2020.1785435

Cited by 4 publications

(1 citation statement)

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“…In vitro biofilm models can also be generated using samples collected from patients/participants as the inoculating fluid, as opposed to a defined consortium of bacteria. The most common is retrievied saliva ( Figure 1H ) and plaque from the oral cavity ( Signori et al., 2016 ), but studies have also used vaginal fluid from patients with chronic candidiasis ( Cordeiro et al., 2020 ).…”

Section: Modelling Biofilm Growthmentioning

confidence: 99%

How to study biofilms: technological advancements in clinical biofilm research

Cleaver,

Garnett

2023

Front. Cell. Infect. Microbiol.

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Biofilm formation is an important survival strategy commonly used by bacteria and fungi, which are embedded in a protective extracellular matrix of organic polymers. They are ubiquitous in nature, including humans and other animals, and they can be surface- and non-surface-associated, making them capable of growing in and on many different parts of the body. Biofilms are also complex, forming polymicrobial communities that are difficult to eradicate due to their unique growth dynamics, and clinical infections associated with biofilms are a huge burden in the healthcare setting, as they are often difficult to diagnose and to treat. Our understanding of biofilm formation and development is a fast-paced and important research focus. This review aims to describe the advancements in clinical biofilm research, including both in vitro and in vivo biofilm models, imaging techniques and techniques to analyse the biological functions of the biofilm.

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Section: Modelling Biofilm Growthmentioning

confidence: 99%