Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines

Vatansever, H. Seda; Sorkun, Kadriye; Gürhan, S. İsmet; Özdal-Kurt, F.; Türköz, Elgin; Gençay, Ömür; Salih, Bekir

doi:10.1016/j.acthis.2009.06.001

Cited by 69 publications

(63 citation statements)

References 36 publications

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“…A portion of this final solution was evaporated to obtain completely dry sample. About 5 mg of dry substance was mixed with 75 μl of dry pyridine and 50 μl bis (trimethylsilyl) trifluoroacetamide heated at 80 °C for 20 min and then supernatant was analyzed by gas chromatography-mass ppectroscopy (GC-MS) (13).…”

Section: Extraction Of Propolismentioning

confidence: 99%

Chemical Analysis and Antimicrobial Effect of Propolis from Hakkari Province of Turkey against Some Pathogenic Microorganisms

Bayram¹,

Bayram²,

Gerçek³

et al. 2017

Eur J Biol

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This study was performed to investigate the antimicrobial effect of propolis from Hakkari province of Turkey and its chemical content by Gas Chromatography-Mass Spectroscopy. In vitro inhibitory activity of propolis was studied by the disc diffusion method against six gram positive, three gram negative bacteria and one yeast like fungi. As a result of chemical analysis, the total flavonoid ratio of the propolis sample was found to be higher than the other compound groups. Pinostrobin chalcone, pinocembrin and chrysin were identified as major flavonoids. Also, all microorganisms tested were susceptible to the propolis extract except for Klebsiella pneumoniae. Minimum inhibition concentration (MIC) values were determined by microbroth dilution assay. MIC values against microorganisms ranged from 25 to 200 µg/mL. Antimicrobial susceptibility test results showed that inhibitory effect our propolis sample was somewhat weaker than ampicillin, but it had a broader spectrum.

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Section: Extraction Of Propolismentioning

confidence: 99%

Chemical Analysis and Antimicrobial Effect of Propolis from Hakkari Province of Turkey against Some Pathogenic Microorganisms

Bayram¹,

Bayram²,

Gerçek³

et al. 2017

Eur J Biol

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“…Many reports have indicated that different types of propolis extracts significantly inhibit cell growth and reduce the differentiation or proliferation of tumor cells (Zliszka et al, 2011;Khalil, 2006). Vatansever et al (2010) reported cytotoxicity of EEP at a concentration of 125 μg/mL to MCF-7 cell line also they found that cytotoxic effects of seven EEP samples collected from the same location is different. While, Choudhari et al (2013) found that IC 50 for ethanolic extract of propolis (EEP) of four cancer cell lines: human colon adenocarcinoma (HT-29), human epithelial colorectal adenocarcinoma (Caco-2), and murine melanoma cell lines (B16F1), MCF-7 to be 250 µg/mL.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity

Shady¹,

Mohamed²,

Sayed-Ahmed³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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“…The percentage of terminal deoxynucleotidyl transferase-mediated dUTP nickend labelling positive cells which were stained among 100 cells was determined. 18 …”

Section: Terminal Deoxynucleotidyl Transferase-mediated Dutp Nick-endmentioning

confidence: 99%

“…18 Evaluation of sections Immunolabelling intensity was graded (independently, by two observers who were blinded to the experimental conditions) as follows: weak, moderate and strong.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

et al. 2017

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Objective: Possible therapeutic and protective benefits of intratympanic autologous serum application in amikacininduced ototoxicity were investigated.Methods: Twenty-four guinea pigs were separated equally into two groups: therapeutic (group A) and protective (group B). Transient evoked otoacoustic emissions were recorded before and after autologous serum application. Apoptotic cells were identified in the organ of Corti, spiral limbus and spiral ganglion by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling ('TUNEL') method.Results: Transient evoked otoacoustic emission responses at 1, 1.4 and 2.8 kHz improved without significance after autologous serum application in group A ( p > 0.05). A significantly protective effect of autologous serum was determined at 4 kHz in group B ( p < 0.05). There were significantly fewer apoptotic cells at the spiral limbus in the therapeutic and protective groups compared to the control group ( p < 0.05).Conclusion: Autologous serum may offer protection against ototoxicity-induced hearing loss, but it cannot restore hearing. Immunohistochemically, autologous serum significantly decreases activation of the intrinsic pathway of pro-apoptotic signalling in mesenchymal cells compared to neurons and neurosensory cells.

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Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines

Cited by 69 publications

References 36 publications

Chemical Analysis and Antimicrobial Effect of Propolis from Hakkari Province of Turkey against Some Pathogenic Microorganisms

Chemical Analysis and Antimicrobial Effect of Propolis from Hakkari Province of Turkey against Some Pathogenic Microorganisms

A Comparative Study on Propolis and Pollen Extracts: Chemical Profile Analysis, Antioxidant and Anticancer Activity

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

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