2014
DOI: 10.3892/mmr.2014.3126
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Abstract: Nuclear factor erythroid 2‑related factor 2 (Nrf2) is a critical regulator of the cellular‑defense response in protection against oxidative injury. Several studies have demonstrated that propofol ameliorates ischemia/reperfusion injury in a number of organs. However, whether propofol exerts renal protection against liver transplantation via Nrf2 activation remains to be elucidated. The aim of the present study was to investigate the effects of orthotopic liver autotransplantation (OLAT) on renal Nrf2 expressio… Show more

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Cited by 14 publications
(9 citation statements)
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References 35 publications
(46 reference statements)
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“…This is considered as one of the most important independent risk factors of AKI. In addition, cyanotic kidney and intestinal endotoxemia induced by occlusion of IVC and remote kidney damage induced by liver transplantation 25 could give rise to OLT-induced AKI 26 .…”
Section: Discussionmentioning
confidence: 99%
“…This is considered as one of the most important independent risk factors of AKI. In addition, cyanotic kidney and intestinal endotoxemia induced by occlusion of IVC and remote kidney damage induced by liver transplantation 25 could give rise to OLT-induced AKI 26 .…”
Section: Discussionmentioning
confidence: 99%
“…Propofol inhibited Cx32 function while attenuating post-AOLT AKI [63]. Another study suggested that propofol exerts a renoprotective effect against AKI after orthotopic liver autotransplantation through the upregulation of the nuclear factor, erythroid 2-related factor 2, a regulator of the cellular-defense response protection against oxidative injury [64]. A recent study found that propofol protects against hepatic IR injury through the regulation of mitogen-activated protein kinase 6 expression by miR-133a-5p [65].…”
Section: General Anesthesiamentioning
confidence: 99%
“…In order to confirm the hypothesis we have mentioned in vivo studies, we further tested it on BEAS-2B cells, a kind of lung epithelial cell line expressing Cx43 [ 28 ]. With the facts that endotoxin always played an important role in ALI after AOLT, and the destruction of intestine motility and barriers after liver transplantation lead to endotoxin explosion and inflammatory cytokines over-production, resulting in susceptible organs injuries [ 29 , 30 ], models of LPS-induced BEAS-2B cells were used to test protective effects of Cx43 inhibition.…”
Section: Resultsmentioning
confidence: 99%