Propofol for sedation during endoscopy: assessment of a computer-controlled infusion system

Intermittent manually controlled versus continuous infusion of propofol for deep sedation during interventional endoscopy: A prospective randomized trial

“…Regarding the use of TCI for endoscopy, in a pilot trial Church et al [28] demonstrated the technical feasibility of the TCI technique for propofol sedation during upper endoscopy in 20 patients. In another trial by Fanti et al [29] in 205 patients who had ERCP under deep sedation with propofol (but without mechanical ventilation), an open TCI system was used.…”

“…Again the quality of sedation was censored high in both groups and no major complications occurred during TCI-propofol sedation. However, all these studies did not randomize TCI versus repetitive bolus administration and were performed in a monitored anesthesia care setting [28,30].…”

Computer-assisted personalized sedation

“…15 The authors evaluated a computer-controlled pump-delivery system that used a mathematical model for the pharmacokinetic behavior of propofol to calculate an infusion rate designed to achieve and maintain a predicted target blood concentration for propofol. The first feasibility assessment of CAPS with the SEDASYS system was published in abstract form in 2006.…”

Determination of the median effective concentration (EC50) of propofol during oesophagogastroduodenoscopy in children

“…In addition, the pharmacokinetic properties of propofol are well suited to the use of a target‐controlled infusion (TCI) system, which can rapidly achieve and maintain a constant plasma concentration. Although previous reports describe the use of propofol administered by TCI for adults undergoing OGD (6,7), no such studies have been published in children. The objective of this study was to utilize TCI in order to define the EC 50 for propofol to children undergoing OGD.…”