Propionibacterium acnes: An Indigenous Bacterium May Be Pathogenic in Several Cutaneous Disease States

Burkhart, Craig G.; Burkhart, Craig N.

doi:10.1001/archderm.137.9.1250

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…It is serologically and biochemically identical to Corynbacteriaum parvum, a potent stimulator of the reticuloendothelial system. It is an indigenous bacteria which has been proven to be pathogenic in several cutaneous disease states including granulomas in sarcoidosis [6]. Moreover, incriminating studies such as API 20A systems, 16sRNA sequencing, DNA-DNA hybridization, XTT reduction method, and scanning electron microscopy have suggested that the P. acnes biofilm is the inciting factor for orthopedic infections [7] and in fatal bacterial granulomas after trauma [8,9].…”

Section: Acne Biofilm: the Central Issue In Acne Pathogenesismentioning

confidence: 99%

A Patient-Oriented Approach to Acne, Rosacea, Perioral Dermatitis, and Isotretinoin with Working Patient Informational/Instructional Sheets and a Review of Pathophysiology and Mechanisms of Therapeutic Agents

Burkhart¹

2008

TODJ

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Patient informational/instructional sheets can be used not only to assist in providing patients with baseline material regarding their condition, but also aid in physicians communicating a treatment protocol. Educational material regarding acne, adult acne, perioral dermatitis, and isotretinoin is included for perusal and discussion. Within this framework, one learns the unifying concept of the Propionibacterium acnes biofilm, methods to maximize production of benzoyl peroxide radicals (the active biological form of this compound), unplugging ability of oral antibiotics, and low-dose isotretinoin therapeutics.

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Section: Acne Biofilm: the Central Issue In Acne Pathogenesismentioning

confidence: 99%