Propionibacterium acnes Activates the IGF-1/IGF-1R System in the Epidermis and Induces Keratinocyte Proliferation

Isard, Olivia; Knol, Anne-Chantal; Ariès, Marie-Françoise; Nguyen, Jean Michel; Khammari, Amir; Castex‐Rizzi, N.; Dréno, Brigitte

doi:10.1038/jid.2010.281

Cited by 82 publications

(67 citation statements)

References 50 publications

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“…Our experimental results showing decreases in SREBP-1 protein and gene expression, a master regulator of lipid synthesis in the sebaceous glands [25,26], might explain critical steps involved with sebosuppression. As possible upstream molecular events, attenuated activation of IGF-1/IGF-1 receptor system after antimicrobial activities of LFCO against P. acnes might lead to suppression of SREBP-1 [27,28]. A decrease in IGF-1R expression after LFCO treatment was observed.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Kwon¹,

Yoon²,

Park³

et al. 2014

Dermatology

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Background: Screening of natural compounds for the development of anti-acne therapeutic agents has been steadily required considering various side effects of acne medications. However, previous studies have mainly focused on experimental tests without clinical trials and histopathological analysis. Objectives: To compare the clinical efficacy, safety and histopathological changes between Lactobacillus-fermented Chamaecyparis obtusa (LFCO) and existing tea tree oil (TTO). Methods: A total of 34 patients were instructed to apply 5% LFCO to the involved areas of a randomly allocated side and 5% TTO extract to the other side for 8 weeks in a double-blind split-face clinical trial. Results: After 8 weeks, inflammatory acne lesions were reduced by 65.3% on the LFCO side and by 38.2% on the TTO side. LFCO was also superior to TTO in the onset time of efficacy (p < 0.05). The LFCO side further demonstrated improvement for non-inflammatory lesions (52.6%, p < 0.05), decreased size of sebaceous glands and sebum output reductions. Patients' subjective satisfaction was also higher without severe adverse reactions. Protein expressions of nuclear factor κB decreased earlier on the LFCO side, and those of interleukin-1a (IL-1a), IL-8, insulin-like growth factor 1 receptor and sterol regulatory element-binding protein 1 decreased subsequently. Ultra-performance liquid chromatography/high-resolution mass spectrometry further demonstrated that the contents of dihydroxybenzoic acid, taxifolin and quercetin were increased in LFCO after fermentation. Conclusions: LFCO treatment was rapid and effective for treating acne lesions compared to TTO. Histopathological findings correlated well with the clinical acne grade and treatment response. This novel natural compound appears to be effective and safe for acne treatment.

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Section: Discussionmentioning

confidence: 99%

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Kwon¹,

Yoon²,

Park³

et al. 2014

Dermatology

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“…Lastly, P. acnes has been shown to increase the production of IGF‐1 by keratinocytes 63 . This can then activate IGF‐1R, mostly located in the basal layer of the epidermis and also induced by P. acnes , leading to proliferation of the keratinocytes and an increase in filaggrin expression through a paracrine pathway 63 . This can potentially be another mechanism by which P. acnes can potentiate comedogenesis.…”

Section: Potentiation Of Comedogenesis After Propionibacterium Acnes mentioning

confidence: 99%

Acne sans P. acnes

Shaheen

González

2012

Acad Dermatol Venereol

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Acne vulgaris is a common disease that carries an enormous financial and psychosocial impact. Androgens, excessive sebum production, ductal hypercornification, changes in the microbial flora, as well as inflammation and immunological host reactions are considered the major contributors to acne pathogenesis. Despite extensive research on acne pathogenesis, the exact sequence of events and their possible mechanisms leading to the development of a microcomedone and its transformation into an inflamed lesion has remained unclear. There is a significant amount of in vitro evidence suggesting a possible pathogenetic role for Propionibacterium acnes in comedogenesis as well as inflammation in inflammatory acne. However, the microbiological data from non‐inflamed as well as inflamed acne lesions, cultured individually, do not entirely support the hypothesis that these micro‐organisms are actually responsible for their initiation. There appears to be comedones and inflamed lesions in which there is no clear evidence of Propionibacterium acnes involvement. Considering this microbiological data, alongside the in vitro evidence, we have tried to delineate the possible sequence of events and their mechanisms, leading to the development of a microcomedone and its transformation into an inflamed lesion. Based on the available literature we have analysed the evidence of both non‐inflamed as well as inflamed acne lesions occurring in the absence of Propionibacterium acnes from the pilosebaceous follicles. We propose that the development of an inflamed acne lesion depends on an imbalance between the pro‐inflammatory and anti‐inflammatory pathways rather than the incitement of inflammation by Propionibacterium acnes.

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“…Abnormal differentiation of follicular keratinocytes with increased cornification is one of major roles in the pathogenesis of acne7. Some researchers have shown effectiveness of ALA-PDT for non-inflammatory acne lesion besides inflammatory lesion48.…”

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confidence: 99%

Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway

Gozali

Zhang

et al. 2016

Sci Rep

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5-aminolevulinic acid-photodynamic therapy (ALA-PDT) is known to be effective in several skin diseases such as acne, actinic keratoses, condyloma acuminata. However, some detailed mechanisms of ALA-PDT to treat these skin diseases still remain elusive. In this study, we aimed to investigate mechanism of ALA-PDT in in-vitro and in-vivo models. For in vitro, we use human keratinocyte cell line (HaCaT) cells. CCK-8 was used to detect cell proliferation activity, immunofluorescence and western blotting method to detect the content of keratin (K)1, K6, K16, protein kinase C (PKC), fibroblast growth factor receptor-2b (FGFR2b) protein, ELISA and RT-PCR to detect expression of interleukin (IL) 1α in the cell supernatant, and detect reactive oxygen species (ROS). For in vivo, we use 20 rabbits to induce hyperkeratosis acne model in their ear. Dermatoscope was used to see follicle hyperkeratosis and skin biopsy to analyze histology and immunohistochemical of PKC, FGFR2b, K1, K6 and K16. Results from this study suggest that ROS stimulated by ALA-PDT lead to inhibition of FGFR2b pathway in PKC downstream to cause reduction of IL1α expression, and eventually, keratinocytes differentiation and proliferation. Our data thus reveal a treatment mechanism of ALA-PDT underlying hyperkeratosis related dermatoses.

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Propionibacterium acnes Activates the IGF-1/IGF-1R System in the Epidermis and Induces Keratinocyte Proliferation

Cited by 82 publications

References 50 publications

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Comparison of Clinical and Histological Effects between Lactobacillus-Fermented Chamaecyparis obtusa and Tea Tree Oil for the Treatment of Acne: An Eight-Week Double-Blind Randomized Controlled Split-Face Study

Acne sans P. acnes

Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway

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