Propionate-Caprylate Mixtures in the Treatment of Dermatomycoses

Peck, Samuel M.

doi:10.1001/archderm.1947.01520110047007

Cited by 25 publications

(1 citation statement)

References 14 publications

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“…This section focuses on preclinical and clinical studies of nonrespiratory infections. Thanks to their antibacterial and antifungal properties, SCFAs have been used since 1947 to successfully treat "external" infections, such as conjunctivitis (8), dermatomycosis (44), and vulvovaginitis (45). More recently, SCFAs have been studied in animal models of colitis, necrotic enteritis, and septic arthritis, among other diseases (Table 1).…”

Section: The Role Of Scfas During Infectionmentioning

confidence: 99%

Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs

2021

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Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a role in the control of infections both through direct action on microorganisms and on host signaling. This review summarizes the main microbicidal effects of SCFAs and discusses studies highlighting the effect of SCFAs in microorganism’s virulence and viability. We also describe the SCFA’s diverse and complex modes of action on the immune system in face of infections with a specific focus on bacterial and viral respiratory infections. A growing body of evidence suggests that SCFAs protect against lung infections. Finally, we present potential strategies that may be leveraged to exploit the biological properties of SCFAs for increasing effectiveness and optimizing patient benefits.

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Section: The Role Of Scfas During Infectionmentioning

confidence: 99%