Prophylaxis Strategies for Contrast-Induced Nephropathy

Abstract

While several risk factors for contrast-induced nephropathy have been identified, the development of an effective prophylaxis strategy for contrast-induced nephropathy has been limited by our poor understanding of the pathophysiology and the clinical significance of this condition. Future research should focus on correctly identifying higher-risk patients and testing therapies in the setting of large well-powered clinical trials.

Efficacy and Safety of Nicorandil for Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Procedures: A Systematic Review and Meta-Analysis

“…44 Remote ischemic preconditioning (RIPC) is also effective in decreasing CIN and major adverse events in patients undergoing PCI, particularly those at high risk for CIN. 35 Despite our study showing no effect of nicorandil on heart failure, it is known that nicorandil can improve heart function in heart failure by widening coronary arteries and increasing blood flow to the heart. It also protects heart cell mitochondria and prevents heart cell death.…”

Conservative outpatient renoprotective protocol in patients with low GFR undergoing contrast angiography: a case series

“…We observed a much lower incidence of CIN in our patients with low eGFRs than in many other studies in this area summarized in a recent review by Pannu et al, 12 without the addition of specifi c hydrating regimens or NAC. There are multiple plausible explanations for this.…”

Comorbidities and Complications in Nonagenarians Undergoing Coronary Angiography and Intervention

“…22) Among these patients, the consequences of dialysis is relatively rare (0.5-2%), but the in-hospital mortality rate was high at 36%. 23) In our study, we reported collectively a relatively higher rate of CIARF (23%). In this group, only one patient (4%) had to be dialized, but unfortunately they later died.…”