Prophylactic effect of aqueous extract ofSesamum indicumseeds on ethanol-induced toxicity in male rats

Abstract

The liver is vulnerable to alcohol-related injury because it is the primary site of alcohol metabolism. Additionally, a number of potentially dangerous by-products are generated as alcohol is broken down in the liver. However, dietary supplements may prevent or relieve some of alcohol's deleterious effects. Therefore, this study was conducted to evaluate the prophylactic effect of aqueous extract of Sesamum indicum (SI) on ethanol induced toxicity in rats. Male Wistar albino rats were divided into control, ethanol, pre-treatment, simultaneous and post-treatment groups. In the prophylactic experiment, Sesamum indicum, (200 mg/kg body weight) was administered by oral gavage for 28 days; two hours before, simultaneously with or two hours after ethanol exposure. Toxicity was induced by administering 45% ethanol (4.8 g/kg bw) by oral gavage. Lipid peroxidation (TBARS) and reduced glutathione (GSH) levels and catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and gluthathione-S-transferase (GST) activities were then determined in the liver, serum triglyceride (TG) levels, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were monitored and histological examination was carried out. The results revealed that ethanol administration led to significant elevation of TBARS level while depleting in the level of GSH as well as CAT, GPx, SOD and GST activities. Similarly, TG level and ALT and AST activities were elevated. The SI pre-treated group significantly inhibited TBARS, restored GSH level, enhanced CAT, GPx, SOD and GST activities and significantly decreased the elevated level of serum TG, ALT and AST activities. SI treatment (simultaneously with ethanol) exhibited similar effects to those of the SI pre-treated groups, while the SI post-treated group did not show the same protection as the Pre-treated group. S. indicum possesses antioxidant and hepatoprotective properties, that eliminate the deleterious effects of toxic metabolites of ethanol.

Biological Evaluation of Anti-androgenic Effect of Some Plant Foods

“…Sesame seed is not only a good source of edible nutrients, but is also widely considered to have medicinal value that includes antioxidant, anti-ageing, antimutagenic, antihypertensive, and anti-inflammatory activities, as well as the ability to inhibit cholesterol absorption from the intestine and synthesis in the liver. The seed is used as a diuretic, emollient, and a tonic for the liver and kidneys [35]. Sesame lignans such as sesamin, episesamin, sesamolin, and γ-tocopherol isolated from Sesamum indicum and Sesamum radiatum seeds among other species have been implicated as having estrogenic and/or anti-estrogenic [36] and antioxidant [36] properties.…”

Phase behaviour of sesame (Sesamum indicum L.) seed oil using supercritical CO2

“…), a member of the Pedaliaceae family, is an important oilseed crop widely cultivated in tropical and subtropical areas and highly drought‐tolerant soils, and thus it is well‐suited for different crop rotation practices . The sesame plant is popularly used as a herbal remedy due to its antioxidant, anti‐aging, antimutagenic, antihypertensive, and anti‐inflammatory effects, as well as its ability to inhibit cholesterol absorption from the intestine and synthesis in the liver . This plant is also an important source of edible oil due to its high essential fatty acid content (ω‐3 and ω‐6), sterols, tocopherols, and tocotrienols .…”

Cardioprotective and antioxidant influence of aqueous extracts from Sesamum indicum seeds on oxidative stress induced by cadmium in wistar rats

“…[ 10 ] Previous studies have shown that SI possesses hepatoprotective, hypoglycemic, antihypertensive, antitumorigenic, and anti-estrogenic properties as well as its ability to increase Vitamin E concentration without the use of Vitamin E supplements and its beneficial effect in treating Parkinson's disease. [ 11 12 ] It has been reported recently to contain free radical scavengers such as flavonoids, saponins, tannins, and phenolic compounds in appreciable quantities. [ 11 ]…”