Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery

Is Antibiotic Prophylaxis Necessary in Mastectomy with Antimicrobial Sutures? A Comparative Analysis

“…Microbiological cultures were obtained in 63 confirmed SSI cases, with Staphylococcus aureus identified as the most common pathogen in both groups. This finding aligns with previous studies that have reported S. aureus as the predominant organism in breast surgery infections [ 5 , 6 , 16 , 17 , 18 , 24 , 25 ]. Despite this, no significant differences in microbiological profiles were observed between the groups ( p = 0.793, Table 4 ), further supporting the conclusion that prophylactic antibiotics, when used alongside triclosan-coated sutures, did not significantly influence the microbiological characteristics of SSIs.…”

“…Given the large number of patients affected by breast cancer and its surgical treatments, this represents a significant gap in the literature. A recent systematic review [ 5 ], which includes many of the major studies referenced in earlier reviews, suggests that antibiotic prophylaxis may reduce SSIs in patients undergoing non-reconstructive breast cancer surgery. However, considerable heterogeneity exists among the included studies, including variations in antibiotic regimens, dosing protocols, follow-up durations (ranging from 5 to 42 days), and surgical procedures.…”

“…Although antibiotic prophylaxis has been shown to reduce SSIs in certain surgical contexts, its benefit in clean procedures such as mastectomy remains debated. Moreover, the routine use of antibiotics is not without risks, as potential adverse effects include drug reactions, increased antimicrobial resistance, and Clostridium difficile infections, which may outweigh the potential benefits [ 5 , 11 , 12 , 28 ].…”

Is Antibiotic Prophylaxis Necessary in Mastectomy with Antimicrobial Sutures? A Comparative Analysis

“…Microbiological cultures were obtained in 63 confirmed SSI cases, with Staphylococcus aureus identified as the most common pathogen in both groups. This finding aligns with previous studies that have reported S. aureus as the predominant organism in breast surgery infections [ 5 , 6 , 16 , 17 , 18 , 24 , 25 ]. Despite this, no significant differences in microbiological profiles were observed between the groups ( p = 0.793, Table 4 ), further supporting the conclusion that prophylactic antibiotics, when used alongside triclosan-coated sutures, did not significantly influence the microbiological characteristics of SSIs.…”

“…Given the large number of patients affected by breast cancer and its surgical treatments, this represents a significant gap in the literature. A recent systematic review [ 5 ], which includes many of the major studies referenced in earlier reviews, suggests that antibiotic prophylaxis may reduce SSIs in patients undergoing non-reconstructive breast cancer surgery. However, considerable heterogeneity exists among the included studies, including variations in antibiotic regimens, dosing protocols, follow-up durations (ranging from 5 to 42 days), and surgical procedures.…”

“…Although antibiotic prophylaxis has been shown to reduce SSIs in certain surgical contexts, its benefit in clean procedures such as mastectomy remains debated. Moreover, the routine use of antibiotics is not without risks, as potential adverse effects include drug reactions, increased antimicrobial resistance, and Clostridium difficile infections, which may outweigh the potential benefits [ 5 , 11 , 12 , 28 ].…”

Preoperative antibiotic prophylaxis in mastectomy: A retrospective comparative analysis of 1413 patients with breast cancer

“…A Cochrane review considering 10 RCTs with 2823 patients concluded that there is no clear consensus on behalf of SAP, but that the SAP probably is effective and should be recommended in BC surgery. 3 According to this review, the risk ratio (RR) for SSI after SAP is 0.67 (95% CI: 0.53–0.85), but only one of the included RCTs yielded results of statistical significance. The overall risk of SSI for all BC surgery in the review was 10.5% without prophylaxis and 7.1% with prophylaxis, exceeding the rate of what we have shown in this study and what is generally considered appropriate for clean surgical operations.…”

Postoperative Infection After Implant-Based Breast Reconstruction: Risk Factors and Clinical Burden in a Large Single-Center Cohort

“…This aspect is particularly relevant because one of the major limitations of the available literature on infection after implant-based breast reconstruction is the marked heterogeneity in perioperative practice. Variations in antibiotic protocols, use of antiseptic irrigations, drain removal criteria, and duration of postoperative antibiotic therapy may substantially influence both infection incidence and its management, thereby complicating the interpretation of published results [ 29 , 30 , 33 , 37 , 38 ]. By reducing protocol-related variability, the present study allows a more focused evaluation of patient- and surgery-related factors.…”

Is Antibiotic Prophylaxis Necessary in Mastectomy with Antimicrobial Sutures? A Comparative Analysis

“…Microbiological cultures were obtained in 63 confirmed SSI cases, with Staphylococcus aureus identified as the most common pathogen in both groups. This finding aligns with previous studies that have reported S. aureus as the predominant organism in breast surgery infections [ 5 , 6 , 16 , 17 , 18 , 24 , 25 ]. Despite this, no significant differences in microbiological profiles were observed between the groups ( p = 0.793, Table 4 ), further supporting the conclusion that prophylactic antibiotics, when used alongside triclosan-coated sutures, did not significantly influence the microbiological characteristics of SSIs.…”

“…Given the large number of patients affected by breast cancer and its surgical treatments, this represents a significant gap in the literature. A recent systematic review [ 5 ], which includes many of the major studies referenced in earlier reviews, suggests that antibiotic prophylaxis may reduce SSIs in patients undergoing non-reconstructive breast cancer surgery. However, considerable heterogeneity exists among the included studies, including variations in antibiotic regimens, dosing protocols, follow-up durations (ranging from 5 to 42 days), and surgical procedures.…”

“…Although antibiotic prophylaxis has been shown to reduce SSIs in certain surgical contexts, its benefit in clean procedures such as mastectomy remains debated. Moreover, the routine use of antibiotics is not without risks, as potential adverse effects include drug reactions, increased antimicrobial resistance, and Clostridium difficile infections, which may outweigh the potential benefits [ 5 , 11 , 12 , 28 ].…”

Preoperative antibiotic prophylaxis in mastectomy: A retrospective comparative analysis of 1413 patients with breast cancer

“…A Cochrane review considering 10 RCTs with 2823 patients concluded that there is no clear consensus on behalf of SAP, but that the SAP probably is effective and should be recommended in BC surgery. 3 According to this review, the risk ratio (RR) for SSI after SAP is 0.67 (95% CI: 0.53–0.85), but only one of the included RCTs yielded results of statistical significance. The overall risk of SSI for all BC surgery in the review was 10.5% without prophylaxis and 7.1% with prophylaxis, exceeding the rate of what we have shown in this study and what is generally considered appropriate for clean surgical operations.…”

Postoperative Infection After Implant-Based Breast Reconstruction: Risk Factors and Clinical Burden in a Large Single-Center Cohort

“…This aspect is particularly relevant because one of the major limitations of the available literature on infection after implant-based breast reconstruction is the marked heterogeneity in perioperative practice. Variations in antibiotic protocols, use of antiseptic irrigations, drain removal criteria, and duration of postoperative antibiotic therapy may substantially influence both infection incidence and its management, thereby complicating the interpretation of published results [ 29 , 30 , 33 , 37 , 38 ]. By reducing protocol-related variability, the present study allows a more focused evaluation of patient- and surgery-related factors.…”

Is Antibiotic Prophylaxis Necessary in Mastectomy with Antimicrobial Sutures? A Comparative Analysis

“…Microbiological cultures were obtained in 63 confirmed SSI cases, with Staphylococcus aureus identified as the most common pathogen in both groups. This finding aligns with previous studies that have reported S. aureus as the predominant organism in breast surgery infections [ 5 , 6 , 16 , 17 , 18 , 24 , 25 ]. Despite this, no significant differences in microbiological profiles were observed between the groups ( p = 0.793, Table 4 ), further supporting the conclusion that prophylactic antibiotics, when used alongside triclosan-coated sutures, did not significantly influence the microbiological characteristics of SSIs.…”

“…Given the large number of patients affected by breast cancer and its surgical treatments, this represents a significant gap in the literature. A recent systematic review [ 5 ], which includes many of the major studies referenced in earlier reviews, suggests that antibiotic prophylaxis may reduce SSIs in patients undergoing non-reconstructive breast cancer surgery. However, considerable heterogeneity exists among the included studies, including variations in antibiotic regimens, dosing protocols, follow-up durations (ranging from 5 to 42 days), and surgical procedures.…”

“…Although antibiotic prophylaxis has been shown to reduce SSIs in certain surgical contexts, its benefit in clean procedures such as mastectomy remains debated. Moreover, the routine use of antibiotics is not without risks, as potential adverse effects include drug reactions, increased antimicrobial resistance, and Clostridium difficile infections, which may outweigh the potential benefits [ 5 , 11 , 12 , 28 ].…”

Preoperative antibiotic prophylaxis in mastectomy: A retrospective comparative analysis of 1413 patients with breast cancer

“…A Cochrane review considering 10 RCTs with 2823 patients concluded that there is no clear consensus on behalf of SAP, but that the SAP probably is effective and should be recommended in BC surgery. 3 According to this review, the risk ratio (RR) for SSI after SAP is 0.67 (95% CI: 0.53–0.85), but only one of the included RCTs yielded results of statistical significance. The overall risk of SSI for all BC surgery in the review was 10.5% without prophylaxis and 7.1% with prophylaxis, exceeding the rate of what we have shown in this study and what is generally considered appropriate for clean surgical operations.…”

Postoperative Infection After Implant-Based Breast Reconstruction: Risk Factors and Clinical Burden in a Large Single-Center Cohort

“…This aspect is particularly relevant because one of the major limitations of the available literature on infection after implant-based breast reconstruction is the marked heterogeneity in perioperative practice. Variations in antibiotic protocols, use of antiseptic irrigations, drain removal criteria, and duration of postoperative antibiotic therapy may substantially influence both infection incidence and its management, thereby complicating the interpretation of published results [ 29 , 30 , 33 , 37 , 38 ]. By reducing protocol-related variability, the present study allows a more focused evaluation of patient- and surgery-related factors.…”