Properties of recombinant extracellular N-terminal domain of human high-affinity copper transporter 1 (hNdCTR1) and its interactions with Cu(<scp>ii</scp>) and Ag(<scp>i</scp>) ions

Orlov, Iurii A.; Sankova, Tatiana P; Skvortsov, A. N.; Klotchenko, Sergey A.; Sakhenberg, E. I.; Mekhova, Aleksandra A; Kisileva, Irina V; Ilyechova, Ekaterina Y.; Puchkova, L. V.

doi:10.1039/d2dt04060c

Dalton Trans.

2023

DOI: 10.1039/d2dt04060c

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Properties of recombinant extracellular N-terminal domain of human high-affinity copper transporter 1 (hNdCTR1) and its interactions with Cu(ii) and Ag(i) ions

Iurii A. Orlov

Tatiana P Sankova

A. N. Skvortsov

et al.

Abstract: High affinity copper transporter 1 (CTR1) is a key link in the transfer of copper (Cu) from the extracellular environment to the cell. Violation in the control system of its...

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Cited by 2 publications

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Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Abdolmaleki,

Aliabadi,

Khaksar

2024

J Cancer Res Clin Oncol

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Copper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in various cancers, including locally advanced rectal cancer and bulky tumors. Several studies have shown that copper nanoparticles can be used as effective agents in chemodynamic therapy, phototherapy, hyperthermia, and immunotherapy. Despite the promising anticancer activity of copper-based compounds, their use in clinical trials is subject to certain limitations. Elevated copper concentrations may promote tumor growth, angiogenesis, and metastasis by affecting cellular processes.

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Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Abdolmaleki,

Aliabadi,

Khaksar

2024

J Cancer Res Clin Oncol

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Chemical background of silver nanoparticles interfering with mammalian copper metabolism

Skvortsov

Ilyechova

Puchkova

2023

Journal of Hazardous Materials

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Properties of recombinant extracellular N-terminal domain of human high-affinity copper transporter 1 (hNdCTR1) and its interactions with Cu(ii) and Ag(i) ions

Abstract: High affinity copper transporter 1 (CTR1) is a key link in the transfer of copper (Cu) from the extracellular environment to the cell. Violation in the control system of its...

Cited by 2 publications

References 110 publications

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Chemical background of silver nanoparticles interfering with mammalian copper metabolism

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