Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery

Masannat, Yazan; Shenoy, Hrishikesh; Speirs, Valerie; Hanby, Andrew M.; Horgan, Kieran

doi:10.1016/j.ejso.2006.01.010

Cited by 57 publications

(35 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[12][13][14] However, any tattooing is anticipated to be temporary rather than permanent but may persist for several months -similar to that expected for blue dye. 23 Any tracer used for SLNB must be retained by the SLNs and not pass on to higher echelon nodes in order to avoid excessive excision of normal nodes. Within this study, a statistically significantly greater number of nodes were excised using the 32 nm tracer compared to the other two tracers.…”

mentioning

confidence: 99%

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Pouw¹,

Ahmed²,

Anninga³

et al. 2015

IJN

View full text Add to dashboard Cite

Introduction Breast cancer staging with sentinel lymph node biopsy relies on the use of radioisotopes, which limits the availability of the procedure worldwide. The use of a magnetic nanoparticle tracer and a handheld magnetometer provides a radiation-free alternative, which was recently evaluated in two clinical trials. The hydrodynamic particle size of the used magnetic tracer differs substantially from the radioisotope tracer and could therefore benefit from optimization. The aim of this study was to assess the performance of three different-sized magnetic nanoparticle tracers for sentinel lymph node biopsy within an in vivo porcine model. Materials and methods Sentinel lymph node biopsy was performed within a validated porcine model using three magnetic nanoparticle tracers, approved for use in humans (ferumoxytol, with hydrodynamic diameter d H =32 nm; Sienna+ ® , d H =59 nm; and ferumoxide, d H =111 nm), and a handheld magnetometer. Magnetometer counts (transcutaneous and ex vivo), iron quantification (vibrating sample magnetometry), and histopathological assessments were performed on all ex vivo nodes. Results Transcutaneous “hotspots” were present in 12/12 cases within 30 minutes of injection for the 59 nm tracer, compared to 7/12 for the 32 nm tracer and 8/12 for the 111 nm tracer, at the same time point. Ex vivo magnetometer counts were significantly greater for the 59 nm tracer than for the other tracers. Significantly more nodes per basin were excised for the 32 nm tracer compared to other tracers, indicating poor retention of the 32 nm tracer. Using the 59 nm tracer resulted in a significantly higher iron accumulation compared to the 32 nm tracer. Conclusion The 59 nm tracer demonstrated rapid lymphatic uptake, retention in the first nodes reached, and accumulation in high concentration, making it the most suitable tracer for intraoperative sentinel lymph node localization.

show abstract

mentioning

confidence: 99%

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Pouw¹,

Ahmed²,

Anninga³

et al. 2015

IJN

View full text Add to dashboard Cite

show abstract

“…11,13 Although methylene blue is more readily available and considerably less expensive than the others, some authors claim that it diffuses more rapidly in peripheral tissues, staining a larger portion of the breast with the blue dye and, to a certain extent, hampering the procedure. [14][15][16] Other authors have reported similar accuracy and sentinel lymph node detection rates with methylene blue and with patent blue. 13,17 There appears to be a lower risk of anaphylaxis with methylene blue compared to the other dyes.…”

Section: Introductionmentioning

confidence: 52%

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

Paulinelli

Freitas‐Junior

Rahal

et al. 2017

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Introduction:Methylene blue is more widely available and less expensive than patent blue, with an apparently lower risk of anaphylaxis. Objective: The two dyes were compared regarding detection of the sentinel lymph node (SLN). Method: A prospective, randomized trial involved 142 patients with invasive breast carcinoma. Sixty-nine (49.3%) assigned to patent blue (group A) and 71 (50.70%) to methylene blue (group B). Thirty-five patients (25.0%) were clinical stage III or IV; 55 (38.7%) had axillary lymph nodes affected; and 69 (49.3%) underwent neoadjuvant chemotherapy. Two patients were excluded because the dye type was not recorded. Results: Patients and tumor characteristics were similar in both groups. SLNs were identified in 47 women (68.1%) in group A and 43 (60.6%) in group B (p=0.35). SLNs were affected in 22 cases (51.2%) in group A and 21 (48.8%) in group B (p=0.62). The SLN was the only node affected in 12 cases (54.5%) in group A and six (33.3%) in group B (p=0.18). The time and degree of difficulty involved in identifying the SLN were similar in both groups. There were no complications or allergies. Conclusion: Methylene blue performed as well as patent blue in identifying the SLN in breast cancer patients.

show abstract

“…Side effects range from minor ones up to life-threatening anaphylaxis [20]. Isosulfan blue has been reported to cause more allergic reactions [21].…”

Section: Discussionmentioning

confidence: 99%

How Long Will I Be Blue? Prolonged Skin Staining Following Sentinel Lymph Node Biopsy Using Intradermal Patent Blue Dye

Gümüş¹,

Gümüş

Jones³

et al. 2013

Breast Care

View full text Add to dashboard Cite

Background: Blue dye used for sentinel lymph node biopsy (SLNB) in breast cancer patients may cause prolonged skin discoloration at the site of injection. The aim of this study was to assess the duration of such skin discoloration. Patients and Methods: 236 consecutive patients who had undergone breast conserving surgery and SLNB for breast cancer were reviewed prospectively from January 2007 to December 2009. Results: Of the 236 patients, 2 had undergone bilateral surgery, and 41 had been examined in consecutive yearly reviews. Blue discoloration remained visible at the injection site after 12, 24, and > 36 months in 36.5, 23.6, and 8.6% of the patients, respectively. Conclusion: The use of patent blue for identification of the sentinel lymph node in patients undergoing breast cancer surgery may result in prolonged discoloration of the skin at the injection site.

show abstract

Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery

Cited by 57 publications

References 58 publications

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

How Long Will I Be Blue? Prolonged Skin Staining Following Sentinel Lymph Node Biopsy Using Intradermal Patent Blue Dye

Contact Info

Product

Resources

About

Properties and characteristics of the dyes injected to assist axillary sentinel node localization in breast surgery

Cited by 57 publications

References 58 publications

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in&nbsp;vivo porcine model

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in&nbsp;vivo porcine model

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients

How Long Will I Be Blue? Prolonged Skin Staining Following Sentinel Lymph Node Biopsy Using Intradermal Patent Blue Dye

Contact Info

Product

Resources

About

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model