Propafenone Overdose: From Cardiogenic Shock to Brugada Pattern

Gil, Júlio; Marmelo, Bruno; Abreu, Luís; Antunes, Hugo; Santos, Luís Antônio Coutrim dos; Cabral, Costa

doi:10.5935/abc.20180033

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion2

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 3 publications

(2 citation statements)

References 7 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we corroborated collateral history from the spouse with that of the patient, and it is highly likely that the toxicity was from propafenone and propranolol ingestion, rather than just a single agent. The presence of type-1 Brugada pattern, seen in both propranolol toxicity and propafenone toxicity 9,11 and the presence of generalized tonic-clinic seizures (also a clinical sign of toxicity caused by both agents) support this. 12 In summary, patients suffering from an overdose of combined therapy have been used.…”

Section: Discussionmentioning

confidence: 82%

“…Lipid emulsion therapy has been successfully used in treating lipophilic drug poisoning (eg, from propranolol) by acting as a “lipid‐sink” that attracts substances away from the brain and heart and toward the lipid‐sink preventing toxic accumulation of the substances in those tissues 14 . In addition to the aforementioned treatments, we believe that early administration of NaHCO 3 should take place in patients exhibiting signs of Na‐channel blockade, due to its ability to prevent cardiac dysrhythmias by reversing Na‐channel blockade 11 …”

Section: Discussionmentioning

confidence: 99%

Propafenone and propranolol dual toxicity

Farooq¹,

Qureshi²,

Kamkoum³

et al. 2020

Journal of the American College of Emergency Physicians Open

View full text Add to dashboard Cite

Propranolol is a highly lipid‐soluble beta‐receptor antagonist and propafenone is a potent class 1c anti‐arrhythmic agent with strong Na‐channel blockade effect. We describe a novel case of dual overdose of propafenone and propranolol resulting in hypotension, generalized seizures, and reduced level of consciousness that was successfully treated. A 52‐year‐old female ingested 500 mg of propranolol and 1.5 g of propafenone. The patient was brought to the emergency department (ED) and exhibited signs of systemic toxicity and reduced level of consciousness. The patient was treated as a case of combined β‐blocker and propafenone toxicity using high dose insulin, NaHCO 3 , glucagon, atropine, and dopamine. She started improving and becoming more alert, with subsequent ECGs revealing normal sinus rhythm. The patient was discharged 4 days later. We believe that early administration of NaHCO 3 should be administered in patients exhibiting signs of Na‐channel blockade.

show abstract

Propafenone Overdose: From Cardiogenic Shock to Brugada Pattern

Cited by 3 publications

References 7 publications

Propafenone and propranolol dual toxicity

Contact Info

Product

Resources

About