2007
DOI: 10.1097/01.ccm.0000266536.14736.03
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Abstract: This is the first study assessing systemic levels of resistin in patients with septic shock/severe sepsis. We show that resistin is a marker of severity of disease and possibly a mediator of the prolonged inflammatory state seen in infected critically ill patients. Further exploration of resistin as a therapeutic target and marker of disease is merited.

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Cited by 121 publications
(111 citation statements)
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“…Upregulated genes present in the top 10 for all groups included resistin (RETN) and IL-1R2 (Supplementary Table S2). RETN is the gene that codes for resistin, which may function as a proinflammatory cytokine (19) and is elevated in infected preterm neonates (20). IL-1R2 is a decoy receptor for IL-1 and highlights the tightly regulated activity of IL-1 in neonates (21).…”
Section: Resultsmentioning
confidence: 99%
“…Upregulated genes present in the top 10 for all groups included resistin (RETN) and IL-1R2 (Supplementary Table S2). RETN is the gene that codes for resistin, which may function as a proinflammatory cytokine (19) and is elevated in infected preterm neonates (20). IL-1R2 is a decoy receptor for IL-1 and highlights the tightly regulated activity of IL-1 in neonates (21).…”
Section: Resultsmentioning
confidence: 99%
“…Patients with defined STSS (n ϭ 18) or culture-confirmed Gram-negative septic shock (n ϭ 17) were selected from three studies (5,13). Serum/ plasma samples were collected at several time points during the acute septic episode.…”
Section: Patient Cohortsmentioning
confidence: 99%
“…In humans, resistin has emerged as a potent proinflammatory molecule associated with acute and chronic inflammatory conditions, whereas its role in glucose metabolism remains controversial (8 -12). Most relevant to this study is our recent finding that systemic resistin levels strongly correlate with the severity of sepsis, and the highest concentrations are noted in patients with septic shock (5). This study aims to further our understanding of resistin responses in severe bacterial infections with respect to cellular sources and bacterial triggers.…”
mentioning
confidence: 99%
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“…55 Levels of both matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) were significantly elevated in a series of 37 patients with severe sepsis compared to similar number of healthy controls, and TIMP was found to be at higher lev-els in those who died, compared to the survivors. 56 Other markers like IL-6,IL-8,IL-18, transforming growth factor -1, interferon-, resistin, cluster of differentiation 64 (CD-64), serum lactate etc., have also been evaluated in various studies 30,[57][58][59] to find out their diagnostic and prognostic potentials in sepsis with variable results.…”
Section: Other Novel Biomarkers For Sepsis On the Horizonmentioning
confidence: 99%