Promotion of Hair Growth by <i>Rosmarinus officinalis</i> Leaf Extract

Murata, Kazuya; Noguchi, Kazuma; Kondo, Masato; Onishi, Mariko; Watanabe, Nozomi; Okamura, Katsumasa; Matsuda, Hideaki

doi:10.1002/ptr.4712

Cited by 61 publications

(47 citation statements)

References 27 publications

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“…It has antiandrogenic effect and hair growth-promoting activity apart from antioxidative, anti-inflammatory, antibacterial, and antitumor effects [43]. In CAM, R. officinalis is often used in aromatherapy to treat anxiety-related conditions and increase alertness, although it has occasionally been used to stimulate hair growth [41].…”

Section: Rosmarinus Officinalismentioning

confidence: 99%

“…They also showed significant promotion of hair growth after 16 days of topical administration. Among the some constituents of R. officinalis [i.e., rosmarinic acid, ursolic acid, 12-methoxycarnosic acid (12-MCA)], it was demonstrated that inhibitory activity of 12-MCA on 5α-reductase was higher than rosmarinic acid and ursalic acid (82.4, 14.2, and 2.5% inhibition at 200 μg/ml, respectively) [43].…”

Section: Rosmarinus Officinalismentioning

confidence: 99%

“…A survey data from UK indicated that 35-69% of patients who have various skin diseases have used CAM in their lifetime [27]. The prevalence of CAM use by dermatology patients were 25.7 and 41% in Singapore [28] and Taiwan [29], respectively, while it ranges from 33.5 [30] to 43.7% in Turkey [31]. As the most frequently complementary medicines used by patients to treat their dermatological diseases have been reported as homeopathy, herbalism, diets, and food supplements in the UK [19,27], the most used types of CAM have been recorded as herbal remedies, special diet, and megavitamin in Taiwan [29].…”

Section: Introductionmentioning

confidence: 99%

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Alternative Medicine for Hair Loss

Yardımcı¹

2017

Hair and Scalp Disorders

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In recent years, people have begun to give further emphasis to the external beauty, especially for their hair. Except drugs with proven effectiveness, complementary and alternative treatment options that have not yet been clarified of their effectiveness and side effect profiles have been used for centuries. Many plants or their extracts are widely used to prevent hair loss and treat alopecia (e.g., androgenetic alopecia, alopecia areata, or traction alopecia) worldwide, especially in Far Eastern countries. The mechanisms of action of these plants are still unknown. Although there are little randomized-controlled studies investigating the effectiveness in the treatment of hair loss, reported results have demonstrated that complementary and alternative medicine will become much more popular in the near future.

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Section: Rosmarinus Officinalismentioning

confidence: 99%

Section: Rosmarinus Officinalismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alternative Medicine for Hair Loss

Yardımcı¹

2017

Hair and Scalp Disorders

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“…Topical administration of R . officinalis leaf extract also showed inhibitory activity of 82.4% and 94.6% at 200 and 500 µg/mL, respectively, against 5αR [24].…”

Section: Plant Raw Materialsmentioning

confidence: 99%

Plants as potential active components in treatment of androgenetic alopecia

et al. 2014

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S u m m a r yAndrogenetic alopecia is caused by the influence of sex hormones on hair follicles and by hereditary factors. Characteristic for that type of alopecia is shortening of the hair growth phase and elongation of the rest phase caused by disturbance of the process of transformation of testosterone into dihydrotestosterone. Treatment of that type of alopecia involves 5α-reductase inhibitors, antagonists of the androgenic receptor or stimulating proliferation of cells to induce the hair growth. A number of plant raw materials work that way, thus they can be used in treatment of this type of alopecia.

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“…Some 5αR inhibitors from natural products have been discovered by our group, i.e., 12-methoxycarnosic acid in Rosmarinus officinalis leaf,[19] ginsenoside Ro in the rhizome of red ginseng,[20] kaikasaponin and soyasaponin in flowers of Pueraria thomsonii [21] and fatty acids and ethinylestradiol in spores of Lygodium japonicum . [22]…”

Section: Introductionmentioning

confidence: 99%

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

Murata¹,

Hayashi²,

Matsumura³

et al. 2013

Phcog Res

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Background:Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5α-reductase (5αR) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice.Materials and Methods:Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5αR inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger's method. The K. parviflora extract was administered to castrated mice for 14 days.Results:K. parviflora extract showed more potent inhibitory activity on 5αR than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days.Conclusion:These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH.

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Promotion of Hair Growth by Rosmarinus officinalis Leaf Extract

Cited by 61 publications

References 27 publications

Alternative Medicine for Hair Loss

Alternative Medicine for Hair Loss

Plants as potential active components in treatment of androgenetic alopecia

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

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