Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells

Kwok, Man Long; Li, Zhen Ping; Law, Tin Yu Samuel; Chan, King Ming

doi:10.1016/j.toxrep.2020.11.005

Cited by 3 publications

(1 citation statement)

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“…The expression of the CTR1 was decreased after Cdcr diet exposure, which was congruent with the data previously described in the literature using a zebrafish model [ 57 ]. During Cd exposure, cells attempted to retain CTR1 in the Golgi apparatus to reduce its retention on the cell membrane to cut off the uptake of Cd and cytotoxicity [ 58 ]. For SGLT1 and NCX1, there are only reports indicating that their transport function is inhibited by Cd, but whether they transport Cd is still unclear [ 59 , 60 , 61 , 62 , 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model

Li,

Pan,

Yin

et al. 2024

IJMS

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Cadmium (Cd) is a heavy metal element with a wide range of hazards and severe biotoxicity. Since Cd can be easily accumulated in the edible parts of plants, the exposure of humans to Cd is mainly through the intake of Cd-contaminated food. However, the intestinal responses to Cd exposure are not completely characterized. Herein, we simulated laboratory and environmental Cd exposure by feeding the piglets with CdCl2-added rice and Cd-contaminated rice (Cdcr) contained diet, as piglets show anatomical and physiological similarities to humans. Subsequent analysis of the metal element concentrations showed that exposure to the two types of Cd significantly increased Cd levels in piglets. After verifying the expression of major Cd transporters by Western blots, multi-omics further expanded the possible transporters of Cd and found Cd exposure causes wide alterations in the metabolism of piglets. Of significance, CdCl2 and Cdcr exhibited different body distribution and metabolic rewiring, and Cdcr had stronger carcinogenic and diabetes-inducing potential. Together, our results indicate that CdCl2 had a significant difference compared with Cdcr, which has important implications for a more intense study of Cd toxicity.

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