Promotion of articular cartilage matrix vesicle mineralization by type I collagen

Jubeck, Brian; Gohr, Claudia M.; Fahey, Mark; Muth, Emily; Matthews, Michele L.; Mattson, Eric C.; Hirschmugl, Carol J.; Rosenthal, Ann K.

doi:10.1002/art.23762

Cited by 44 publications

(35 citation statements)

References 30 publications

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“…In the latter, a genetic component leading to upregulation of genes involved in mineralization has been discussed [7][8][9]. CPPD is a common cause of inflammation and pain, clinically known as pseudogout [10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative

et al. 2016

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Objectives To evaluate the ability of different MRI sequences to detect chondrocalcinosis within knee cartilage and menisci, and to analyze the association with joint degeneration. Methods Subjects with radiographic knee chondrocalcinosis (n = 90, age 67.7 ± 7.3 years, 50 women) were selected from the Osteoarthritis Initiative and matched to controls without radiographic chondrocalcinosis (n = 90). Visualization of calcium-containing crystals (CaC) was compared between 3D T1-weighted gradient-echo (T1GE), 3D dual echo steady-state (DESS), 2D intermediate-weighted (IW), and proton density (PD)-weighted fast spin-echo (FSE) sequences obtained with 3T MRI and correlated with a semiquantitative CaC score obtained from radiographs. Structural abnormalities were assessed using Whole-Organ MRI Score (WORMS) and logistic regression models were used to compare cartilage compartments with and without CaC. Results Correlations between CaC counts of MRI sequences and degree of radiographic calcifications were highest for GE (r T1GE = 0.73, P < 0.001; r DESS = 0.68, P < 0.001) compared to other sequences (P > 0.05). Meniscus WORMS was significantly higher in subjects with chondrocalcinosis compared to controls (P = 0.005). Cartilage defects were significantly more frequent in compartments with CaC than without (patella: P = 0.006; lateral tibia: P < 0.001; lateral femur condyle: P = 0.017). Conclusions Gradient-echo sequences were most useful for the detection of chondrocalcinosis and presence of CaC was associated with higher prevalence of cartilage and meniscal damage.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative

et al. 2016

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“…1). Isolated ACVs generate arthritogenic calcium crystals in vitro identical to those seen in human synovial fluid [15]. ACVs are easily isolated from normal cartilage as well as osteoarthritic cartilage [16].…”

Section: Mechanisms Of Articular Cartilage Vesicle Mineralizationmentioning

confidence: 99%

“…ACVs generate CPP crystals in the presence of ATP. BCP crystal formation predominates when B-glycerophosphate is the primary phosphate source [15,18]. Specific activities of ATP metabolizing ecto-enzymes on ACVs drive mineralization by affecting levels of Pi and PPi (Fig.…”

Section: Factors Regulating Articular Cartilage Vesicle Mineralizationmentioning

confidence: 99%

“…In more direct studies, mineralization was assessed when ACVs were embedded in agarose gels containing various matrix components. Normal cartilage matrix, modeled by adding proteoglycans and type II collagen to the gel, suppressed ACV-induced mineralization [15]. Mimicking osteoarthritic extracellular matrix by adding type I collagen increased ACV-induced mineralization [15].…”

Section: Factors Regulating Articular Cartilage Vesicle Mineralizationmentioning

confidence: 99%

“…Normal cartilage matrix, modeled by adding proteoglycans and type II collagen to the gel, suppressed ACV-induced mineralization [15]. Mimicking osteoarthritic extracellular matrix by adding type I collagen increased ACV-induced mineralization [15]. Thus, the compositional changes that occur in osteoarthritic matrix promote ACV mineralization.…”

Section: Factors Regulating Articular Cartilage Vesicle Mineralizationmentioning

confidence: 99%

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Articular cartilage vesicles and calcium crystal deposition diseases

Rosenthal

2016

Current Opinion in Rheumatology

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Purpose of review Articular cartilage vesicles (ACVs) are small extracellular vesicles that serve as foci of pathologic calcium crystal deposition in articular cartilage matrix. In this review, I have summarized the role of ACVs in calcium crystal formation and discuss recent findings that impact our understanding of the content, behavior, and origin of ACVs in healthy and diseased joints. The burgeoning interest in extracellular vesicles in other fields renders this a timely and relevant topic. Recent findings I have highlighted recent studies demonstrating that some ACVs originate in the autophagic pathway in healthy articular chondrocytes. I have reviewed accumulating evidence that nonmineralizing functions of ACVs contribute to osteoarthritis. I have also discussed new work supporting a role for extracellular vesicles in interleukin-1 β-induced mineralization and in mediating the catabolic effects of synovial inflammation in osteoarthritis. Summary We are making slow and steady progress in understanding the origin and function of ACVs and other relevant extracellular vesicles in arthritis. Further work in this interesting area is warranted.

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Association of Chondrocalcinosis in Knee Joints With Pain and Synovitis: Data From the Osteoarthritis Initiative

Han

Kim

Niu

et al. 2017

Arthritis Care & Research

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Objective To evaluate the relationship between chondrocalcinosis and pain or synovitis in knee joints by examining data from the Osteoarthritis Initiative (OAI). Methods Data were obtained from the OAI public use data sets. The relationship between chondrocalcinosis on baseline knee radiograph and pain at baseline and at 4 years was examined. Analyses were adjusted for age, gender, body mass index, and Kellgren-Lawrence (KL) grade and the correlation between two knees in a subject was controlled using generalized estimating equations. The relationship between chondrocalcinosis and synovitis on MRI was examined by comparing knees with chondrocalcinosis at baseline and age, gender, KL grade-matched knees with no chondrocalcinosis. We read MRIs of a subset of knees for synovitis using MRI Osteoarthritis Knee Score (MOAKS) on baseline and 4-year MRI. Results Knees with chondrocalcinosis (n=162) more often had pain compared to knees without chondrocalcinosis (n=2030) at baseline and had higher Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores both at baseline (2.4 (95% CI 1.9,2.9) vs 1.8 (1.7,1.9)) and at 4 years (2.5 (1.9,3.1) vs 1.6 (1.5,1.8)) as well as higher Intermittent and Constant Osteoarthritis Pain (ICOAP) intermittent pain scores at 4 years. There was no difference in MOAKS synovitis scores at baseline and at 4 years between the chondrocalcinosis group (n=102) and the control group (n=99). Conclusion Knees with chondrocalcinosis had increased pain and did not have higher synovitis scores on MRI compared to knees without chondrocalcinosis. The mechanisms by which chondrocalcinosis is associated with increased pain remain to be determined.

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Promotion of articular cartilage matrix vesicle mineralization by type I collagen

Cited by 44 publications

References 30 publications

Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative

Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative

Articular cartilage vesicles and calcium crystal deposition diseases

Association of Chondrocalcinosis in Knee Joints With Pain and Synovitis: Data From the Osteoarthritis Initiative

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