2017
DOI: 10.3389/fendo.2017.00153
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Abstract: Obesity leads to a loss of muscle mass and impaired muscle regeneration. In obese individuals, pathologically elevated levels of prolyl hydroxylase domain enzyme 2 (PHD2) limit skeletal muscle hypoxia-inducible factor-1 alpha and vascular endothelial growth factor (VEGF) expression. Loss of local VEGF may further impair skeletal muscle regeneration. We hypothesized that PHD2 inhibition would restore vigorous muscle regeneration in a murine model of obesity. Adult (22-week-old) male mice were fed either a high-… Show more

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Cited by 12 publications
(13 citation statements)
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“…9 PHD2 inhibition resulting in augmented hypoxia signaling similarly improves muscle regeneration in a murine model of obesity. 30 Regulation of particular HIFs may indeed have differential effects and may account for some of the differences demonstrated in these previous studies. 31 Our study focused on the niche effect of hypoxia signaling and ARNT on myogenesis.…”
Section: Discussionmentioning
confidence: 87%
“…9 PHD2 inhibition resulting in augmented hypoxia signaling similarly improves muscle regeneration in a murine model of obesity. 30 Regulation of particular HIFs may indeed have differential effects and may account for some of the differences demonstrated in these previous studies. 31 Our study focused on the niche effect of hypoxia signaling and ARNT on myogenesis.…”
Section: Discussionmentioning
confidence: 87%
“…The oxidative characteristic of soleus muscle is generally fatigue resistant ( Alford et al, 1987 ; Hodgson et al, 2001 ; Asmussen et al, 2003 ) and administration of HFS decreases sensory and motor conduction velocity in soleus muscle ( Obrosova et al, 2007 ; Davidson et al, 2010 ; Guilford et al, 2011 ). Pathologically elevated levels of prolyl hydroxyl domain-2 in mice fed HFS drives impairment in muscle regeneration and limits VEGF expression ( Sinha et al, 2017a ).…”
Section: Effects Of Hfs On Expression Of Skeletal Muscle Proteinsmentioning
confidence: 99%
“…Mouse models -Generation of the Hnrnpu floxed allele has been described previously (Ye et al, 2015). Skeletal muscle specific deletion of Hnrnpu was achieved by crossing with the HSA-Cre (Miniou et al, 1999) Cryoinjury model and histological analysis -Cryoinjury model was performed as previously described (Sinha et al, 2017). Briefly, mice were anesthetized with isoflurane and the skin over the tibialis anterior (TA) was depilated and prepped with sterile alcohol.…”
Section: Methodsmentioning
confidence: 99%