“…It suppresses insulin sensitivity in liver, and hepatic deletion enhanced HIF-2α stability, and thereby Irs2/Akt2 signaling (96). β Cell-specific effects of PHD3 have been reported in abstract form (97), and increased glycolysis and use of fatty acids for energy were found. On normal diet, this had no deleterious effects, but with HFD, mice developed glucose intolerance.…”