Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat

Swain, Rodney A.; Harris, A. Basil; Wiener, Edzard; Dutka, Michael V.; Morris, H Douglas; Theien, B.E; Konda, Sreenivas; Engberg, Kristin; Lauterbur, Paul C.; Greenough, William T.

doi:10.1016/s0306-4522(02)00664-4

Cited by 546 publications

(392 citation statements)

References 61 publications

Supporting

Mentioning

364

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, the elevation in fitness across the training intervention was positively correlated with the change in cerebrovascular reactivity, indicating that the increased aerobic capacity is at least, in part, responsible for the improved cerebrovascular reactivity. Swain et al (2003) used MRI in rats to assess the cerebral responses to 10 % CO 2 prior to and following at least 30 days of voluntary exercise or sedentary living. They found a 22 % increase in signal intensity during CO 2 inhalation (when compared to pre-training) in the exercise group, indicating a more pronounced CBF response to hypercapnia, which supports the findings from this study and is independent of inferring an increased perfusion based on velocity measurements.…”

Section: Effect Of Training On Resting Variablesmentioning

confidence: 99%

“…One cross-sectional study indicated that higher fitness is related to larger frontal and temporal volumes of grey matter (Colcombe et al 2006). Other potential mechanisms may involve more endotheliumdependent vasodilatation as a result of more NO bioavailability (Green et al 2004) and/or cerebral angiogenesis (Rhyu et al 2010;Swain et al 2003;Ding et al 2006;Black et al 1990). In support of this, ageinduced cerebral atrophy appears to be less marked in those with higher aerobic fitness (Colcombe et al 2003).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Murrell

Cotter

Thomas

et al. 2012

AGE

165

180

View full text Add to dashboard Cite

Chronic reductions in cerebral blood flow (CBF) and cerebrovascular reactivity to CO 2 are risk factors for cerebrovascular disease. Higher aerobic fitness is associated with higher CBF at any age; however, whether CBF or reactivity can be elevated following an exercise training intervention in healthy individuals is unknown. The aim of this study was to assess the effect of exercise training on CBF and cerebrovascular reactivity at rest and during exercise in young and older individuals. Ten young (23±5 years; body mass index ) previously sedentary individuals breathed 5 % CO 2 for 3 min at rest and during steady-state cycling exercise (30 and 70 % heart rate range (HRR)) prior to and following a 12-week aerobic exercise intervention. Effects of training on middle cerebral artery blood velocity (MCAv) at rest were unclear in both age groups. The absolute MCAv response to exercise was greater in the young (9 and 9 cm s −1 (30 and 70 % HRR, respectively) vs. 5 and 4 cm s −1 (older), P<0.05) and was similar following training. Cerebrovascular reactivity was elevated following the 12-week training at rest (2.87±0.76 vs. 2.54± 1.12 cm s −1 mm Hg −1 , P00.01) and during exercise, irrespective of age. The finding of a training-induced elevation in cerebrovascular reactivity provides further support for exercise as a preventative tool in cerebrovascular and neurological disease with ageing.

show abstract

Section: Effect Of Training On Resting Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Murrell

Cotter

Thomas

et al. 2012

AGE

165

180

View full text Add to dashboard Cite

show abstract

“…One hypothesis is an improvement in cerebral vascular functioning and brain perfusion. Animal 85 and human 86 studies have shown that physical activity can stimulate brain perfusion and angiogenesis within a few weeks of aerobic training. Physical activity is associated with increased blood perfusion of brain regions that modulate attention.…”

Section: Basic Researchmentioning

confidence: 99%

Healthy Brain Aging: Role of Exercise and Physical Activity

Rolland¹,

Kan²,

Vellas³

2010

Clinics in Geriatric Medicine

View full text Add to dashboard Cite

“…Both L-DOPA and bromocriptine have a marked motor stimulant effect in animal models of PD, but the motor activation produced by bromocriptine does not involve dyskinesia (Lundblad et al, 2002;Pearce et al, 1998). This allowed us to ask the question, whether an increased motor activity per se may bring about microvascular remodeling in the basal ganglia, in analogy to the exercise-induced angiogenesis reported in other brain regions (Ekstrand et al, 2008a;Kleim et al, 2002;Swain et al, 2003). As bromocriptine exerts its motor stimulant ('anti-akinetic') effects predominantly by acting on the D2 receptor (Kvernmo et al, 2006;Perachon et al, 1999), it yields a different profile of DA receptor activation compared with L-DOPA.…”

Section: Introductionmentioning

confidence: 99%

Differential Involvement of D1 and D2 Dopamine Receptors in L-DOPA-Induced Angiogenic Activity in a Rat Model of Parkinson's Disease

Lindgren

Ohlin

Cenci

2009

Neuropsychopharmacol

View full text Add to dashboard Cite

Angiogenesis occurs in the brains of Parkinson's disease patients, but the effects of dopamine replacement therapy on this process have not been examined. Using rats with 6-hydroxydopamine lesions, we have compared angiogenic responses induced in the basal ganglia by chronic treatment with either L-DOPA, or bromocriptine, or a selective D1 receptor agonist (SKF38393). Moreover, we have asked whether L-DOPA-induced angiogenesis can be blocked by co-treatment with either a D1-or a D2 receptor antagonist (SCH23390 and eticlopride, respectively), or by an inhibitor of extracellular signal-regulated kinases 1 and 2 (ERK1/2) (SL327). L-DOPA, but not bromocriptine, induced dyskinesia, which was associated with endothelial proliferation, upregulation of immature endothelial markers (nestin) and downregulation of endothelial barrier antigen in the striatum and its output structures. At a dose inducing dyskinesia (1.5 mg/kg/day), SKF38393 elicited angiogenic changes similar to L-DOPA. Antagonism of D1-but not D2 class receptors completely suppressed both the development of dyskinesia and the upregulation of angiogenesis markers. In fact, L-DOPA-induced endothelial proliferation was markedly exacerbated by low-dose D2 antagonism (0.01 mg/kg eticlopride). Inhibition of ERK1/2 by SL327 attenuated L-DOPA-induced dyskinesia and completely inhibited all markers of angiogenesis. These results highlight the specific link between treatment-induced dyskinesias and microvascular remodeling in the dopamine-denervated brain. L-DOPA-induced angiogenesis requires stimulation of D1 receptors and activation of ERK1/2, whereas the stimulation of D2 receptors seems to oppose this response.

show abstract

Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat

Cited by 546 publications

References 61 publications

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training

Healthy Brain Aging: Role of Exercise and Physical Activity

Differential Involvement of D1 and D2 Dopamine Receptors in L-DOPA-Induced Angiogenic Activity in a Rat Model of Parkinson's Disease

Contact Info

Product

Resources

About