Prolonged cutaneous herpes zoster in acquired immunodeficiency syndrome

Comparative Pathology and Pathogenesis of Spontaneous and Experimentally Induced Fibropapillomas of Green Turtles (Chelonia mydas)

“…8 Epidermal keratinocyte and dermal fibroblast proliferation were consistent defining features of GTFP and were the earliest changes recognized in experimentally induced tumors. Epithelial proliferation has been associated with herpesvirus infections in other vertebrates, including several species of fish, 3 leopard frogs, 42 green wall lizards, 53 African elephants, 32 and immunosuppressed humans, 26,39,60,63 and is also a feature of the papular form of gray-patch disease, caused by chelonid herpesvirus 1, in green turtles after hatching. 54 Recently, herpesviruses have been implicated in the pathogenesis of mesenchymal tumors, Kaposi's sarcoma in humans, 6 and retroperitoneal fibromatosis in macaques.…”

Prolonged Herpes Zoster in a Patient Infected with the Human Immunodeficiency Virus

“…In our case, the prolonged course of acyclovir therapy did not lead to the selection of an acyclovir resistant strain. However, it is true that, in immunocompromised hosts, drug resistant strains tend to be more often detected during the acyclovir therapy than in immunocompetent hosts (14,15). In such cases of prolonged herpes zoster with AIDS, molecular epidemiological study of VZV is necessary to distinguish whether the sequential strains are the same.…”

A Rapid Phenotypic Assay for Detection of Acyclovir-Resistant Varicella-Zoster Virus with Mutations in the Thymidine Kinase Open Reading Frame

“…However, this is not the case. Indeed, one can expect that most strains will be correctly identified by the colony reduction assay, for only a few strains with mutations in pol (4,14,28) have been reported, and these represent no more than 5% of all ACV r VZV strains (3,4,13,14,20,21,23,24,26,28,30,33,36,37,42,46). In addition, VZV TK mutations selected in tdk mutant bacteria can confer either deficient or altered TK phenotypes (40).…”