2006
DOI: 10.1007/s11434-006-1328-5
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Proliferation and differentiation into endothelial cells of human bone marrow mesenchymal stem cells (MSCs) on poly DL-lactic-co-glycolic acid (PLGA) films

Abstract: The functional realization is the most important problem in vascular tissue engineering. The small-caliber blood vessel substitutes are prone to thrombi, which results in functional loss of blood vessels. However, this is probably due to the imperfection of endothelial layer in the substitutes. In this study, MSCs were seeded on a series of porous PLGA films with various porosity and pore size made by sodium chloride (NaCl) particulate leaching, and cell proliferation on each film was inspected. The film made … Show more

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Cited by 13 publications
(3 citation statements)
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“…Stem cells are a population possessing (1) self-renewal capacity, (2) long-term viability and (3) multilineage potential. The multilineage potential of embryonic stem cells and adult stem cells from the bone marrow has been characterized extensively [3,4] . During embryonic development, stem cells from the blastocyst give rise to cell progenies that seem to become progressively restricted in their phenotypic potential to generate mature tissues [5] .…”
mentioning
confidence: 99%
“…Stem cells are a population possessing (1) self-renewal capacity, (2) long-term viability and (3) multilineage potential. The multilineage potential of embryonic stem cells and adult stem cells from the bone marrow has been characterized extensively [3,4] . During embryonic development, stem cells from the blastocyst give rise to cell progenies that seem to become progressively restricted in their phenotypic potential to generate mature tissues [5] .…”
mentioning
confidence: 99%
“…Since the first use of synthetic biodegradable sutures in the latter half of the 1960s, 1 biodegradable polymers prepared from poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and other degradable poly(a-hydroxy acids) have been widely used in biomedical applications approved by the FDA. Poly (lactide-co-glycolide) acid (PLGA) based on PLA and PGA has been used for fabricating temporary prostheses, 2-5 threedimensional porous scaffolds and films, [6][7][8][9][10][11][12][13][14][15][16][17] controlled/sustained release drug delivery vehicles, [18][19][20][21][22][23][24][25][26] wound closure (surgical sutures and staples), [27][28][29] and implantable thera-peutic devices (orthopedic fixation devices and cardiovascular stents and grafts), [30][31][32][33][34][35][36] all of which have made many significant achievements in tissue engineering, regenerative medicine, gene therapy, controlled drug delivery, and bionanotechnology. 37 PLGA has its hydrolytically labile chemical bonds in its backbone and has been shown to primarily undergo bulk degradation in vivo via chemical hydrolysis of the hydrolytically unstable ester bonds into lactic acid and glycolic acid.…”
Section: Introductionmentioning
confidence: 99%
“…This process leads to generate poly(lactic acid) (PLA) and poly(glycolic acid) (PGA), and the final degradation products are CO 2 and H 2 O which can be excreted from the body by the tricarboxylic acid cycle safely. 2 Regard to its great biocompatibility and good processability, PLGA was approved by the FDA and widely used in biomedical applications such as degradable and absorbable sutures, 3,4 implants, [5][6][7][8][9][10][11] artificial skin graft and scaffolds, [12][13][14][15][16][17][18][19][20][21] and drug release systems. [22][23][24][25][26][27][28][29][30] Especially, as cardiovascular incidents are dramatically increasing, the applications of PLGA in heart patches 31 and polymeric biodegradable stents (BDSs) [32][33][34][35] have been drawn more and more attention.…”
Section: Introductionmentioning
confidence: 99%