Prolactinomas: present day management

The effect of the menopause on prolactin levels in patients with hyperprolactinaemia

“…During this time the management of prolactinomas has evolved. Dopamine agonists have become available and are now the first line treatment for patients such as those in this study (Soule & Jacobs, 1995). Bromocriptine was the most frequently used dopamine agonist in this study.…”

Prolactinoma and pregnancy

“…Bromocriptine should therefore be recommended as primary therapy in women with macroprolactinomas 34,35 . However, women with macroprolactinomas should be advised against conception until normal visual fields are documented and a repeat pituitary magnetic resonance scan has shown tumour shrinkage to within the pituitary fossa, which may take three to six months.…”

New drugs for hyperprolactinaemia

“…In most patients with hyperprolactinaemia bromocriptine lowers prolactin levels, restores gonadal function, stops galactorrhoea and if a prolactinoma is present, causes it to shrink 1 , 2. Bromocriptine is usually given daily by mouth in two or three divided doses.…”