Prolactin receptors (PRL-R) and breast cancer

Androgen regulation of prolactin‐receptor gene expression in MCF‐7 and MDA‐MB‐453 human breast cancer cells

“…In humans, the action of lactogenic hormone shows a similar dependence on steroid hormones (reviewed by . This dependence may also occur in human breast cancer as the PRLR and the sex steroid hormone receptors are co-expressed (Bonneterre et al, 1986).In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

“…In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

Androgen regulation of prolactin‐receptor gene expression in MCF‐7 and MDA‐MB‐453 human breast cancer cells

“…In humans, the action of lactogenic hormone shows a similar dependence on steroid hormones (reviewed by . This dependence may also occur in human breast cancer as the PRLR and the sex steroid hormone receptors are co-expressed (Bonneterre et al, 1986).In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

“…In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone

“…Another growth factor for breast cancer is prolactin (PRL). High levels of PRL have been proven to be associated with a poor prognosis in metastatic breast cancer patients (Bhatavdekar et al, 1990), while the expression of PRL receptor on breast cancer cells constitutes a good prognostic factor (Bonneterre and Peyrat, 1989). However, the role of PRL and PRL receptor in breast cancer is still controversial.…”

Androgen regulation of prolactin‐receptor gene expression in MCF‐7 and MDA‐MB‐453 human breast cancer cells

“…In humans, the action of lactogenic hormone shows a similar dependence on steroid hormones (reviewed by . This dependence may also occur in human breast cancer as the PRLR and the sex steroid hormone receptors are co-expressed (Bonneterre et al, 1986).In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

“…In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone

“…Another growth factor for breast cancer is prolactin (PRL). High levels of PRL have been proven to be associated with a poor prognosis in metastatic breast cancer patients (Bhatavdekar et al, 1990), while the expression of PRL receptor on breast cancer cells constitutes a good prognostic factor (Bonneterre and Peyrat, 1989). However, the role of PRL and PRL receptor in breast cancer is still controversial.…”

Androgen regulation of prolactin‐receptor gene expression in MCF‐7 and MDA‐MB‐453 human breast cancer cells

“…In humans, the action of lactogenic hormone shows a similar dependence on steroid hormones (reviewed by . This dependence may also occur in human breast cancer as the PRLR and the sex steroid hormone receptors are co-expressed (Bonneterre et al, 1986).In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

“…In human breast cancer, up to 72% of biopsies are PRLRpositive (reviewed by Bonneterre and Peyrat, 1989) and up to 64% of biopsies have immunologically detectable prolactin present (Purnell et al, 1982). Clinical data concerning the role of prolactin in human breast cancer are inconclusive (reviewed by Vonderhaar and Biswas, 1987); however, experimental investigation has shown clear responses of human breasttumour tissues and cells to lactogenic hormones.…”

Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone

“…Another growth factor for breast cancer is prolactin (PRL). High levels of PRL have been proven to be associated with a poor prognosis in metastatic breast cancer patients (Bhatavdekar et al, 1990), while the expression of PRL receptor on breast cancer cells constitutes a good prognostic factor (Bonneterre and Peyrat, 1989). However, the role of PRL and PRL receptor in breast cancer is still controversial.…”