Prolactin may serve as a regulator to promote vocal fold wound healing

Wang, Haizhou; Li, Xueyan; Lu, Jiuwei; Jones, Paul H.; Xu, Wen

doi:10.1042/bsr20200467

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ECM also has a major function in cell adhesion (hsa04510) (73) and intestinal healing is also associated with intestinal stem cell differentiation and proliferation (hsa04550) (74,75). Notably, Hippo signalling (hsa04390) also has a role in regulating the regeneration of organs such as the liver, heart, nervous system and skin as well as intestine (76) and also prolactin (hsa04917) has been suggested to have an important role in re-epithelialization and promote wound healing (77). According to a previous study, plasma and wound fluid levels of proangiogenic proteins were elevated in patients after CRC resection for 3 to 5 weeks, leading to the hypothesis that the wound healing may stimulate tumour growth in residual tumour deposits (78).…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNA expression over the course of colorectal cancer treatment

et al. 2021

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the third-most common cancer type in males and the second-most common cancer type in females, and has the second-highest overall mortality rate worldwide. Approximately 50% of patients in stage I-III develop metastases, mostly localized to the liver. All physiological conditions occurring in the organism are also reflected in the levels of circulating microRNAs (miRNAs/miRs) in patients. miRNAs are a class of small, non-coding, single-stranded RNAs consisting of 18-25 nucleotides, which have important roles in various cellular processes. The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR-210-5p, miR-155-5p, miR-21-5p, miR-103a-3p, miR-191-5p and miR-16-5p) as biomarkers for monitoring patients undergoing adjuvant treatment of CRC. Total RNA was extracted from the plasma of patients with CRC prior to surgery, in the early post-operative period (n=60) and 3 months after surgery (n=14). The levels of the selected circulating miRNAs were measured with the miRCURY LNA miRNA PCR system and fold changes were calculated using the standard ∆∆Cq method. DIANA-miRPath analysis was used to evaluate the role of significantly deregulated miRNAs. The results indicated significant upregulation of miR-155-5p, miR-21-5p and miR-191-5p, and downregulation of miR-16-5p directly after the surgery. In paired follow-up samples, the most significant upregulation was detected for miR-106a-5p and miR-16-5p, and the most significant downregulation was for miR-21-5p. Pathway analysis outlined the role of the differentially expressed miRNAs in cancer development, but the same pathways are also involved in wound healing and regeneration of intestinal epithelium. It may be suggested that these processes should also be considered in studies investigating sensitive and easily detectable circulating biomarkers for recurrence in patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Circulating miRNA expression over the course of colorectal cancer treatment

et al. 2021

View full text Add to dashboard Cite

show abstract

Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology

Langan

2024

IJMS

View full text Add to dashboard Cite

The hormone prolactin (PRL) is best recognised for its indispensable role in mammalian biology, specifically the regulation of lactation. Bearing in mind that the mammary gland is a modified sweat gland, it is perhaps unsurprising to discover that PRL also plays a significant role in cutaneous biology and is implicated in the pathogenesis of a range of skin diseases, often those reportedly triggered and/or exacerbated by psychological stress. Given that PRL has been implicated in over 300 biological processes, spanning reproduction and hair growth and thermo- to immunoregulation, a comprehensive understanding of the relationship between PRL and the skin remains frustratingly elusive. In an historical curiosity, the first hint that PRL could affect skin biology came from the observation of seborrhoea in patients with post-encephalitic Parkinsonism as a result of another global pandemic, encephalitis lethargica, at the beginning of the last century. As PRL is now being postulated as a potential immunomodulator for COVID-19 infection, it is perhaps timeous to re-examine this pluripotent hormone with cytokine-like properties in the cutaneous context, drawing together our understanding of the role of PRL in skin disease to illustrate how targeting PRL-mediated signalling may represent a novel strategy to treat a range of skin diseases and hair disorders.

show abstract

Prolactin may serve as a regulator to promote vocal fold wound healing

Cited by 2 publications

References 23 publications

Circulating miRNA expression over the course of colorectal cancer treatment

Circulating miRNA expression over the course of colorectal cancer treatment

Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology

Contact Info

Product

Resources

About