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“…As expected the uvrA mutant was highly sensitive to UV light, at doses which had only minor effects on the wild-type strain (Figure 1a). The extent of susceptibility of the uvrA mutant paralleled that of the uvrB mutant, as would be expected since UvrA and UvrB act together in damage recognition (5,14). Complementation of the uvrA mutant restored survival to levels similar to those of the wild-type, confirming that the increased susceptibility was due to the inactivation of uvrA .…”
Section: Resultssupporting
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“…As expected the uvrA mutant was highly sensitive to UV light, at doses which had only minor effects on the wild-type strain (Figure 1a). The extent of susceptibility of the uvrA mutant paralleled that of the uvrB mutant, as would be expected since UvrA and UvrB act together in damage recognition (5,14). Complementation of the uvrA mutant restored survival to levels similar to those of the wild-type, confirming that the increased susceptibility was due to the inactivation of uvrA .…”
Section: Resultssupporting
“…UvrA plays an important role in the recognition of DNA damage for repair by NER (4,5). To confirm the importance of UvrA in the repair of typical NER substrates and to assess its role in surviving more physiologically relevant DNA damage, a strain of M. tuberculosis was constructed in which uvrA was inactivated.…”
Section: Resultsmentioning
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