Progressive Lipodystrophy and Lipoatrophic Diabetes

Taylor, William B.

doi:10.1001/archderm.1961.01580130037005

Cited by 33 publications

(9 citation statements)

References 12 publications

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“…His health was excellent". Our observation of discordance in identical twins and that by Taylor and Honeycutt [20] clearly demonstrate a nongenetic etiology. In the paper by Barraquer-Ferr6 [3] the only description of the relatives was given by the afflicted patient herself: "From her description we conclude Fig.…”

Section: Pathogenesissupporting

confidence: 68%

“…These facts lead to the conclusion that these diseases are acquired, and not, as some authors have postulated [7,3,20], genetically fixed. Repeated examinations failed to reveal any deficiency either of the complement factors or of the nephritogenic factor.…”

Section: Pathogenesismentioning

confidence: 92%

“…None of these cases can stand a critical evaluation with regard to the question of genetic origin. Similarly, in the paper by Taylor and Honeycutt [20] the only report given by the patient is that "he had a cousin and an uncle with similar faces". His health was excellent".…”

Section: Pathogenesismentioning

confidence: 96%

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Membranoproliferative Glomerulonephritis und partielle Lipodystrophie

et al. 1976

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The course of disease of a patient with membranoproliferative glomerulonephritis and partial lipodystrophy is described. The case is further characterized by a deficiency of C3 and C3- activator, by normal values of C4, by evidence of the nephritogenic factor, by raised fibrin degradation products and by an unselective proteinuria. The course of the glomerulonephritis runs parallel to a pronounced susceptibility to infection (at first varicella, tonsillitis and measles, later pneumonia, meningitis, encephalitis and hepatitis). On account of a nephrotic syndrome and an initative impairment of the renal function, a cytostatic treatment was begun, which although raising the C3 level did not influence the further course of the disease. As the patient has a healthy identical twin sister without lipodystrophy, who shows no reduction in C3 and no nephritogenic factor, this case proves that these diseases are acquired and not genetically determined.

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Section: Pathogenesissupporting

confidence: 68%

Section: Pathogenesismentioning

confidence: 92%

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Membranoproliferative Glomerulonephritis und partielle Lipodystrophie

et al. 1976

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“…Laboratory examination at age 16 gave the follow¬ ing results (normal values in parentheses) : total pro¬ tein, 8.5 gm/100 ml (6.5-8.1) ; protein-bound iodine, 5jug (4/ig-8fig) ; nonprotein nitrogen, 23 mg/100 ml (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) ; total lipids, 510 mg/100 ml (350-800) ; cho¬ lesterol esters, 72.4% (60%-80%) ; total cholesterol, 140 mg/100 ml (175-275); phospholipids, 162 mg/ Accepted for publication Dec 21, 1964 Dermatological examination confirmed the presence of generalized lipodystrophy. The patient had abundant kinky scalp hair with pronounced hirsutism of the neck, arms, and legs.…”

mentioning

confidence: 99%

“…Senior and Gellis 22 noted a significant incidence of renal disease in patients with partial lipodystrophy (those with cephalothoracic distribution). These patients also have symptoms of nervous system dysfunction, hepatomegaly, and decreased glucose tolerance, \ s=d\ References 1,4,8,9,12,17,22,23,26. although not as frequently as patients with total lipodystrophy. Dermatologie Manifestations.-There has been difficulty in ascertaining the dermatologie findings in the reported cases of lipodystrophy, since as a rule they were not examined by dermatologists, and subsequently the descrip¬ tions of their skin lesions are vague and almost meaningless.…”

mentioning

confidence: 99%