Progressive Lipodystrophy

Lipodystrophy following hepatitis infection: A causative relationship?

“…One interesting feature in this case was the woman's history of hepatitis infection prior to the onset of lipodystrophy together with persistent hepatitis B surface antigen positivity and antibodies to hepatitis B core antigen. Lipodystrophy has been seen following measles and in these subjects the distribution of partial lipodystrophy coincided with the area maximally affected by the measles rash 10 . It is interesting to speculate whether measles caused lipodystrophy due to pre‐existing hypocomplementaemia or whether measles might have caused the hypocomplementaemia.…”

“…Lipodystrophy has been seen following measles and in these subjects the distribution of partial lipodystrophy coincided with the area maximally affected by the measles rash. 10 It is interesting to speculate whether measles caused lipodystrophy due to pre-existing hypocomplementaemia or whether measles might have caused the hypocomplementaemia. Similarly it can be postulated that the lipodystrophy in our patient could have been caused by the hepatitis B infection.…”

Partial lipodystrophy presenting with myopathy

“…Examination of muscle power was normal (Jones 1956). In a review of 50 cases of PLD at the Mayo clinic, MN, USA, fatiguability was a common finding (Poley and Stickler 1963).…”

Panniculitis in Childhood

“…Fat in the pelvic area and thighs is normal or increased, giving the patient a characteristic appearance. Onset occurs most commonly in childhood and adolescence, and is not infrequently subsequent to an acute febrile iUness such as measles (44)(45)(46)(47)(48). It affects females 4 times more frequently than males (23).…”

“…The less common forms of partial LD are characterized by loss of subcutaneous fat from the extremities, or extremities and torso in various combinations (Table 2) (46,49,(60)(61)(62)(63)(64)(65)(66)(67)(68)(69)(70). Case reports involving several family members have identified a dominant inheritance pattern, either autosomal or X-linked, leading to the designation of familial partial LD.…”