Progressive, atrophying, chronic granulomatous dermohypodermitis. Autoimmune disease?

Granulomatous Slack Skin: Treatment with Extensive Surgery and Review of the Literature

“…This observation corresponds clinically and histologically to the GSS first described by Convit et al [1]. There are some histological similarities with mycosis fungoides, but GSS is specifically characterized by numerous giant cells with more nuclei than in mycosis fungoides.…”

Granulomatous Slack Skin in Childhood

“…Using the appropriate stains, fragments of elastic fibers are visible in the cytoplasm of giant cells. If this interpretation is con-ect, it would reaffirm the pathogenetic role of autoimmune phenoma suggested by Convit et al (1) in the original description, although these autoimmune phenomena should be understood as a host response to a distinct cutaneous lymphoma.…”

Granulomatous Slack Skin

“…Since the report of Convit et al [4] on GSS, 34 patients (including the 3 patients in this report) have been described.…”