Progression from mild cognitive impairment to dementia: A 3-year longitudinal study

Abstract

The findings confirm that simple clinical data such as age, cognitive ability at baseline, and rate of cognitive decline are important predictors of progression from mild cognitive impairment to dementia over 3 years.

Mortality in Mild Cognitive Impairment: A Longitudinal Study in Memory Clinics

“…This finding is consistent with previous research which has found decline in cognition predicts mortality in the general population [17, 38] and that more recent decline in cognition is a stronger predictor of mortality in the elderly than cognitive impairment that is more stable over time [39, 40]. Previous research has also shown that greater decline in cognition over time predicts progression from MCI to dementia independently of baseline levels [16]. In the current study, however, decline in function, but not cognition, predicted mortality, perhaps because function might provide a more reliable and specific index of significant health impairment than cognition.…”

“…Despite these limitations, our findings confirm that longitudinal assessment with simple clinical tools can be helpful in determining patients’ prognosis [16]. Given the relative ease with which these instruments can be administered, evaluating the trajectory of cognition and function over time, rather than only considering absolute values, appears to be important when assessing patients with MCI.…”

Mortality in Mild Cognitive Impairment: A Longitudinal Study in Memory Clinics

“…This finding is consistent with previous research which has found decline in cognition predicts mortality in the general population [17, 38] and that more recent decline in cognition is a stronger predictor of mortality in the elderly than cognitive impairment that is more stable over time [39, 40]. Previous research has also shown that greater decline in cognition over time predicts progression from MCI to dementia independently of baseline levels [16]. In the current study, however, decline in function, but not cognition, predicted mortality, perhaps because function might provide a more reliable and specific index of significant health impairment than cognition.…”

“…Despite these limitations, our findings confirm that longitudinal assessment with simple clinical tools can be helpful in determining patients’ prognosis [16]. Given the relative ease with which these instruments can be administered, evaluating the trajectory of cognition and function over time, rather than only considering absolute values, appears to be important when assessing patients with MCI.…”

Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies

“…Apathy is also common in elderly individuals without cognitive impairment, 58 and increases with age in otherwise healthy community-dwelling individuals. 30 The analysis of mean NPI apathy scores revealed a significant mean difference of .34 points, which is a very modest difference in a clinical setting. Still, previous studies report that even mild symptoms of apathy and other neuropsychiatric symptoms increase the risk of progression from MCI to dementia, with potential importance in clinical practice.…”

Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review

“…9,24 However, currently there is no routine cognitive function screening for ACS patients to identify CI in the early stages. 25 In our review, 15–52% of ACS patients were identified with mild CI during post-event screening; these patients would likely have gone undetected without screening. 15,16,25…”

“…25 In our review, 15–52% of ACS patients were identified with mild CI during post-event screening; these patients would likely have gone undetected without screening. 15,16,25…”

Mortality in Mild Cognitive Impairment: A Longitudinal Study in Memory Clinics

“…This finding is consistent with previous research which has found decline in cognition predicts mortality in the general population [17, 38] and that more recent decline in cognition is a stronger predictor of mortality in the elderly than cognitive impairment that is more stable over time [39, 40]. Previous research has also shown that greater decline in cognition over time predicts progression from MCI to dementia independently of baseline levels [16]. In the current study, however, decline in function, but not cognition, predicted mortality, perhaps because function might provide a more reliable and specific index of significant health impairment than cognition.…”

“…Despite these limitations, our findings confirm that longitudinal assessment with simple clinical tools can be helpful in determining patients’ prognosis [16]. Given the relative ease with which these instruments can be administered, evaluating the trajectory of cognition and function over time, rather than only considering absolute values, appears to be important when assessing patients with MCI.…”

Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies

“…Apathy is also common in elderly individuals without cognitive impairment, 58 and increases with age in otherwise healthy community-dwelling individuals. 30 The analysis of mean NPI apathy scores revealed a significant mean difference of .34 points, which is a very modest difference in a clinical setting. Still, previous studies report that even mild symptoms of apathy and other neuropsychiatric symptoms increase the risk of progression from MCI to dementia, with potential importance in clinical practice.…”

Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review

“…9,24 However, currently there is no routine cognitive function screening for ACS patients to identify CI in the early stages. 25 In our review, 15–52% of ACS patients were identified with mild CI during post-event screening; these patients would likely have gone undetected without screening. 15,16,25…”

“…25 In our review, 15–52% of ACS patients were identified with mild CI during post-event screening; these patients would likely have gone undetected without screening. 15,16,25…”

Mortality in Mild Cognitive Impairment: A Longitudinal Study in Memory Clinics

“…This finding is consistent with previous research which has found decline in cognition predicts mortality in the general population [17, 38] and that more recent decline in cognition is a stronger predictor of mortality in the elderly than cognitive impairment that is more stable over time [39, 40]. Previous research has also shown that greater decline in cognition over time predicts progression from MCI to dementia independently of baseline levels [16]. In the current study, however, decline in function, but not cognition, predicted mortality, perhaps because function might provide a more reliable and specific index of significant health impairment than cognition.…”

“…Despite these limitations, our findings confirm that longitudinal assessment with simple clinical tools can be helpful in determining patients’ prognosis [16]. Given the relative ease with which these instruments can be administered, evaluating the trajectory of cognition and function over time, rather than only considering absolute values, appears to be important when assessing patients with MCI.…”

Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies

“…Apathy is also common in elderly individuals without cognitive impairment, 58 and increases with age in otherwise healthy community-dwelling individuals. 30 The analysis of mean NPI apathy scores revealed a significant mean difference of .34 points, which is a very modest difference in a clinical setting. Still, previous studies report that even mild symptoms of apathy and other neuropsychiatric symptoms increase the risk of progression from MCI to dementia, with potential importance in clinical practice.…”

Prevalence and patterns of cognitive impairment in acute coronary syndrome patients: A systematic review

“…9,24 However, currently there is no routine cognitive function screening for ACS patients to identify CI in the early stages. 25 In our review, 15–52% of ACS patients were identified with mild CI during post-event screening; these patients would likely have gone undetected without screening. 15,16,25…”

“…25 In our review, 15–52% of ACS patients were identified with mild CI during post-event screening; these patients would likely have gone undetected without screening. 15,16,25…”