Progress in self-healing hydrogels assembled by host–guest interactions: preparation and biomedical applications

Jin, Jiahong; Cai, Lili; Jia, Yong‐Guang; Liu, Sa; Chen, Yunhua; Li, Ren

doi:10.1039/c8tb02547a

Cited by 100 publications

(67 citation statements)

References 115 publications

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“…In recent years, the rapid development of self‐healing materials benefited from the unique ability that they can restore the original properties and functionalities after damage, to improve their durability, safety, and longevity . Hence, the self‐healing materials have been developed for applications in various fields including structural materials, coating, soft robotics and artificial skin, and medicine engineering . As is well known, many people used the dynamic covalent and noncovalent bonds to design the self‐healing materials .…”

Section: Introductionmentioning

confidence: 99%

Coordination Bonds and Diels–Alder Bonds Dual Crosslinked Polymer Networks of Self‐healing Polyurethane

Lin

Sheng

Liu

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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A dual crosslinked self‐healing polyurethane was prepared with robust mechanical properties through the dynamic reversible pyridine‐Fe3+ coordination bonds and Diels–Alder (DA) covalent bonds dual crosslinking strategy. Moreover, the mechanical properties and self‐healing ability of polyurethane can be tuned readily by different ratio of the coordination bonds and DA bonds. Under external load, the coordination bonds serve as sacrificial bonds are broken to dissipate energy, the DA bonds can keep the shape of sample. With the coordination bonds participation, the damaged samples can be healed under moderate heating treatment or with the aid of FeCl3 solution. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2228–2234

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Section: Introductionmentioning

confidence: 99%

Coordination Bonds and Diels–Alder Bonds Dual Crosslinked Polymer Networks of Self‐healing Polyurethane

Lin

Sheng

Liu

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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“…Host molecules are macrocycles characterized by including an internal cavity that allows the accommodation of different guest molecules. In the last decades, different host cycles have been studied for the synthesis of hydrogels by inclusion complexation, such as cyclodextrins (CDs) or cucurbit[n]urils (CB[n]) or calixarenes [ 76 ]. Among all of them, cyclodextrins (CD) are undoubtedly the most known host compounds, which have been widely employed to develop self-healing hydrogels due to their biocompatibility and non-toxicity.…”

Section: Self-healing Mechanismsmentioning

confidence: 99%

“…Adamantine, ferrocene, cholic acid, or azobenzene are some of the most representative guest molecules able to form a stable inclusion complex with cyclodextrins and their derivatives [ 76 ]. Therefore, functionalization of synthetic and natural polymers with both cited pendant host and guest functionalities to their complementary interaction has been the most reported via the design of host-guest mediated self-healing hydrogels.…”

Section: Self-healing Mechanismsmentioning

confidence: 99%

Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

et al. 2020

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In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.

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“…13,14 Also, the dynamic linkages in the network endow the hydrogels with prominent self-healing characteristics, which allow the gels to self-mend the damage intrinsically and automatically. [15][16][17] Aggregation-induced emission (AIE) has been considered as a great discovery worldwide. [18][19][20][21] According to the mechanism of the restriction of intramolecular motion (RIM) proposed by Tang and coworkers, 22 the AIE luminogens with a "propellershape" molecular structure exhibit a restricted intramolecular motion in the aggregated state, causing enhancement in the uorescence emission by the reduction of the nonradiative transition.…”

Section: Introductionmentioning

confidence: 99%

A self-healing supramolecular hydrogel with temperature-responsive fluorescence based on an AIE luminogen

Zhang

Yan

et al. 2020

RSC Adv.

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Progress in self-healing hydrogels assembled by host–guest interactions: preparation and biomedical applications

Abstract: Preparation and biomedical applications of self-healing hydrogels assembled from hosts of cyclodextrins and cucurbit[n]urils with various guests were reviewed.

Cited by 100 publications

References 115 publications

Coordination Bonds and Diels–Alder Bonds Dual Crosslinked Polymer Networks of Self‐healing Polyurethane

Coordination Bonds and Diels–Alder Bonds Dual Crosslinked Polymer Networks of Self‐healing Polyurethane

Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

A self-healing supramolecular hydrogel with temperature-responsive fluorescence based on an AIE luminogen

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